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Hybrid Magnetic Hydrogel: A Potential System for Controlled Drug Delivery by Means of Alternating Magnetic Fields
Centro Interuniversitario Sistemi Medici Avanzati (C.R.I.S.M.A.), Colle di Val d’Elsa Viale Matteotti 15, Siena, 53034 Colle di Val d’Elsa, Italy
* Author to whom correspondence should be addressed.
Received: 28 February 2012; in revised form: 19 April 2012 / Accepted: 25 April 2012 / Published: 3 May 2012
Abstract: Novel hybrid magnetic hydrogels have demonstrated their influence in several areas, particularly in biomedical science where these innovative materials are showing interesting applications for controlled drug delivery. A hybrid hydrogel with CoFe2O4 nanoparticles (NPs) as cross-linker agents of carboxymethylcellulose (CMC) polymer was obtained with the aim of testing it as a system for controlled drug release. The NPs were functionalized with (3-aminopropyl)-trimethoxysilane (APTMS) in order to introduce-NH2 groups on the surface. Infrared spectroscopy, XPS and electrochemical analysis were performed to quantify the amino coating. The presence of magnetic nanoparticles makes the system suitable for an application with magnetic stimulus. Preliminary studies performed with alternating magnetic fields indicate a release of the drug-like molecules previously loaded in the matrix.
Keywords: magnetic nanoparticles; magnetic hydrogel; functionalization of nanoparticles; voltammetry analysis of nanoparticles; AFM analysis
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MDPI and ACS Style
Giani, G.; Fedi, S.; Barbucci, R. Hybrid Magnetic Hydrogel: A Potential System for Controlled Drug Delivery by Means of Alternating Magnetic Fields. Polymers 2012, 4, 1157-1169.
Giani G, Fedi S, Barbucci R. Hybrid Magnetic Hydrogel: A Potential System for Controlled Drug Delivery by Means of Alternating Magnetic Fields. Polymers. 2012; 4(2):1157-1169.
Giani, Gabriele; Fedi, Serena; Barbucci, Rolando. 2012. "Hybrid Magnetic Hydrogel: A Potential System for Controlled Drug Delivery by Means of Alternating Magnetic Fields." Polymers 4, no. 2: 1157-1169.