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Calcite Biohybrids as Microenvironment for Stem Cells
Avram and Stella Goldstein-Goren Department of Biotechnology Engineering, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel
Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel
* Author to whom correspondence should be addressed.
Received: 20 February 2012; in revised form: 11 April 2012 / Accepted: 12 April 2012 / Published: 23 April 2012
Abstract: A new type of composite 3D biomaterial that provides extracellular cues that govern the differentiation processes of mesenchymal stem cells (MSCs) has been developed. In the present study, we evaluated the chondrogenecity of a biohybrid composed of a calcium carbonate scaffold in its calcite polymorph and hyaluronic acid (HA). The source of the calcite scaffolding is an exoskeleton of a sea barnacle Tetraclita rifotincta (T. rifotincta), Pilsbry (1916). The combination of a calcium carbonate-based bioactive scaffold with a natural polymeric hydrogel is designed to mimic the organic-mineral composite of developing bone by providing a fine-tuned microenvironment. The results indicate that the calcite-HA interface creates a suitable microenvironment for the chondrogenic differentiation of MSCs, and therefore, the biohybrid may provide a tool for tissue-engineered cartilage.
Keywords: calcium carbonate; mesenchymal stem cells (MSCs); chondrogenesity; hyaluronic acid (HA)
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MDPI and ACS Style
Astachov, L.; Nevo, Z.; Vago, R. Calcite Biohybrids as Microenvironment for Stem Cells. Polymers 2012, 4, 1065-1083.
Astachov L, Nevo Z, Vago R. Calcite Biohybrids as Microenvironment for Stem Cells. Polymers. 2012; 4(2):1065-1083.
Astachov, Liliana; Nevo, Zvi; Vago, Razi. 2012. "Calcite Biohybrids as Microenvironment for Stem Cells." Polymers 4, no. 2: 1065-1083.