Polymers 2012, 4(2), 1065-1083; doi:10.3390/polym4021065
Article

Calcite Biohybrids as Microenvironment for Stem Cells

Received: 20 February 2012; in revised form: 11 April 2012 / Accepted: 12 April 2012 / Published: 23 April 2012
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A new type of composite 3D biomaterial that provides extracellular cues that govern the differentiation processes of mesenchymal stem cells (MSCs) has been developed. In the present study, we evaluated the chondrogenecity of a biohybrid composed of a calcium carbonate scaffold in its calcite polymorph and hyaluronic acid (HA). The source of the calcite scaffolding is an exoskeleton of a sea barnacle Tetraclita rifotincta (T. rifotincta), Pilsbry (1916). The combination of a calcium carbonate-based bioactive scaffold with a natural polymeric hydrogel is designed to mimic the organic-mineral composite of developing bone by providing a fine-tuned microenvironment. The results indicate that the calcite-HA interface creates a suitable microenvironment for the chondrogenic differentiation of MSCs, and therefore, the biohybrid may provide a tool for tissue-engineered cartilage.
Keywords: calcium carbonate; mesenchymal stem cells (MSCs); chondrogenesity; hyaluronic acid (HA)
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MDPI and ACS Style

Astachov, L.; Nevo, Z.; Vago, R. Calcite Biohybrids as Microenvironment for Stem Cells. Polymers 2012, 4, 1065-1083.

AMA Style

Astachov L, Nevo Z, Vago R. Calcite Biohybrids as Microenvironment for Stem Cells. Polymers. 2012; 4(2):1065-1083.

Chicago/Turabian Style

Astachov, Liliana; Nevo, Zvi; Vago, Razi. 2012. "Calcite Biohybrids as Microenvironment for Stem Cells." Polymers 4, no. 2: 1065-1083.

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