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Polymers 2012, 4(2), 1056-1064; doi:10.3390/polym4021056
Article

Templated Formation of Hydroxyapatite Nanoparticles from Self-Assembled Nanogels Containing Tricarboxylate Groups

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Received: 27 February 2012; in revised form: 10 April 2012 / Accepted: 11 April 2012 / Published: 20 April 2012
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Abstract: Nanosized hydroxyapatite (HAp) materials have received much attention in the context of their advanced biomedical applications, including tissue engineering and drug delivery systems. Hybridization of nanosized HAp with organic molecules is a promising approach to facilitate the preparation of HAp nanomaterials. Here, templated mineralization using self-assembled nanogels modified with tricarboxylate groups was performed to yield the hybrid HAp nanomaterial. In the pH gradient method, the nanogel acted as an excellent template for the formation of well-dispersed HAp particles. Transmission electron microscopy, selected area electron diffraction patterns and energy-dispersive X-ray spectroscopy of these particles revealed that amorphous nanoparticles of amorphous calcium phosphate formed first, followed by transformation to crystalline hydroxyapatite.
Keywords: nanogel; hydroxyapatite; organic-inorganic hybrid; calcium phosphate nanogel; hydroxyapatite; organic-inorganic hybrid; calcium phosphate
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Sasaki, Y.; Yamane, S.; Kurosu, K.; Sawada, S.-I.; Akiyoshi, K. Templated Formation of Hydroxyapatite Nanoparticles from Self-Assembled Nanogels Containing Tricarboxylate Groups. Polymers 2012, 4, 1056-1064.

AMA Style

Sasaki Y, Yamane S, Kurosu K, Sawada S-I, Akiyoshi K. Templated Formation of Hydroxyapatite Nanoparticles from Self-Assembled Nanogels Containing Tricarboxylate Groups. Polymers. 2012; 4(2):1056-1064.

Chicago/Turabian Style

Sasaki, Yoshihiro; Yamane, Setsuko; Kurosu, Kei; Sawada, Shin-Ichi; Akiyoshi, Kazunari. 2012. "Templated Formation of Hydroxyapatite Nanoparticles from Self-Assembled Nanogels Containing Tricarboxylate Groups." Polymers 4, no. 2: 1056-1064.


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