Polymers 2012, 4(2), 1056-1064; doi:10.3390/polym4021056
Article

Templated Formation of Hydroxyapatite Nanoparticles from Self-Assembled Nanogels Containing Tricarboxylate Groups

Yoshihiro Sasaki 1,2 email, Setsuko Yamane 3 email, Kei Kurosu 1 email, Shin-Ichi Sawada 4,5 email and Kazunari Akiyoshi 1,4,5,* email
1 Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan 2 PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan 3 Department of Chemistry and Biochemistry, Numazu National College of Technology, 3600 Ooka, Numazu 410-8501, Japan 4 Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan 5 ERATO, Japan Science and Technology Agency, 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan
* Author to whom correspondence should be addressed.
Received: 27 February 2012; in revised form: 10 April 2012 / Accepted: 11 April 2012 / Published: 20 April 2012
(This article belongs to the Special Issue Selected Papers from the 3rd International Congress on Biohydrogels (Biohydrogels 2011))
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Abstract: Nanosized hydroxyapatite (HAp) materials have received much attention in the context of their advanced biomedical applications, including tissue engineering and drug delivery systems. Hybridization of nanosized HAp with organic molecules is a promising approach to facilitate the preparation of HAp nanomaterials. Here, templated mineralization using self-assembled nanogels modified with tricarboxylate groups was performed to yield the hybrid HAp nanomaterial. In the pH gradient method, the nanogel acted as an excellent template for the formation of well-dispersed HAp particles. Transmission electron microscopy, selected area electron diffraction patterns and energy-dispersive X-ray spectroscopy of these particles revealed that amorphous nanoparticles of amorphous calcium phosphate formed first, followed by transformation to crystalline hydroxyapatite.
Keywords: nanogel; hydroxyapatite; organic-inorganic hybrid; calcium phosphate

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MDPI and ACS Style

Sasaki, Y.; Yamane, S.; Kurosu, K.; Sawada, S.-I.; Akiyoshi, K. Templated Formation of Hydroxyapatite Nanoparticles from Self-Assembled Nanogels Containing Tricarboxylate Groups. Polymers 2012, 4, 1056-1064.

AMA Style

Sasaki Y, Yamane S, Kurosu K, Sawada S-I, Akiyoshi K. Templated Formation of Hydroxyapatite Nanoparticles from Self-Assembled Nanogels Containing Tricarboxylate Groups. Polymers. 2012; 4(2):1056-1064.

Chicago/Turabian Style

Sasaki, Yoshihiro; Yamane, Setsuko; Kurosu, Kei; Sawada, Shin-Ichi; Akiyoshi, Kazunari. 2012. "Templated Formation of Hydroxyapatite Nanoparticles from Self-Assembled Nanogels Containing Tricarboxylate Groups." Polymers 4, no. 2: 1056-1064.

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