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Polymers 2011, 3(4), 1684-1733; doi:10.3390/polym3041684

Biodegradable Cell-Seeded Nanofiber Scaffolds for Neural Repair

Department of Electrical and Computer Engineering, The University of British Columbia, Vancouver, BC V6T 1Z4, Canada
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Received: 24 August 2011 / Revised: 14 September 2011 / Accepted: 6 October 2011 / Published: 10 October 2011
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Abstract

Central and peripheral neural injuries are traumatic and can lead to loss of motor and sensory function, chronic pain, and permanent disability. Strategies that bridge the site of injury and allow axonal regeneration promise to have a large impact on restoring quality of life for these patients. Engineered materials can be used to guide axonal growth. Specifically, nanofiber structures can mimic the natural extracellular matrix, and aligned nanofibers have been shown to direct neurite outgrowth and support axon regeneration. In addition, cell-seeded scaffolds can assist in the remyelination of the regenerating axons. The electrospinning process allows control over fiber diameter, alignment, porosity, and morphology. Biodegradable polymers have been electrospun and their use in tissue engineering has been demonstrated. This paper discusses aspects of electrospun biodegradable nanofibers for neural regeneration, how fiber alignment affects cell alignment, and how cell-seeded scaffolds can increase the effectiveness of such implants. View Full-Text
Keywords: neural regeneration; electrospinning; nanotechnology; polymer; nanofibers; bioconduits; biomaterials; axonal guidance neural regeneration; electrospinning; nanotechnology; polymer; nanofibers; bioconduits; biomaterials; axonal guidance
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Han, D.; Cheung, K.C. Biodegradable Cell-Seeded Nanofiber Scaffolds for Neural Repair. Polymers 2011, 3, 1684-1733.

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