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Polymers 2011, 3(4), 1673-1683; doi:10.3390/polym3041673
Article

Metal-Free Polymethyl Methacrylate (PMMA) Nanoparticles by Enamine “Click” Chemistry at Room Temperature

1
 and 1,2,3,*
Received: 1 September 2011; in revised form: 15 September 2011 / Accepted: 6 October 2011 / Published: 7 October 2011
(This article belongs to the Special Issue Click Chemistry in Polymer Science)
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Abstract: “Click” chemistry has become an efficient avenue to unimolecular polymeric nanoparticles through the self-crosslinking of individual polymer chains containing appropriate functional groups. Herein we report the synthesis of ultra-small (7 nm in size) polymethyl methacrylate (PMMA) nanoparticles (NPs) by the “metal-free” cross-linking of PMMA-precursor chains prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization containing b-ketoester functional groups. Intramolecular collapse was performed by the one-pot reaction of b-ketoester moieties with alkyl diamines in tetrahydrofurane at r.t. (i.e., by enamine formation). The collapsing process was followed by size exclusion chromatography and by nuclear magnetic resonance spectroscopy. The size of the resulting PMMA-NPs was determined by dynamic light scattering. Enamine “click” chemistry increases the synthetic toolbox for the efficient synthesis of metal-free, ultra-small polymeric NPs.
Keywords: enamine “click” chemistry; intramolecular collapse; unimolecular polymeric nanoparticles enamine “click” chemistry; intramolecular collapse; unimolecular polymeric nanoparticles
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Buruaga, L.; Pomposo, J.A. Metal-Free Polymethyl Methacrylate (PMMA) Nanoparticles by Enamine “Click” Chemistry at Room Temperature. Polymers 2011, 3, 1673-1683.

AMA Style

Buruaga L, Pomposo JA. Metal-Free Polymethyl Methacrylate (PMMA) Nanoparticles by Enamine “Click” Chemistry at Room Temperature. Polymers. 2011; 3(4):1673-1683.

Chicago/Turabian Style

Buruaga, Lorea; Pomposo, José A. 2011. "Metal-Free Polymethyl Methacrylate (PMMA) Nanoparticles by Enamine “Click” Chemistry at Room Temperature." Polymers 3, no. 4: 1673-1683.


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