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Polysaccharides: The “Click” Chemistry Impact
Polymers 2011, 3(4), 1673-1683; doi:10.3390/polym3041673

Metal-Free Polymethyl Methacrylate (PMMA) Nanoparticles by Enamine “Click” Chemistry at Room Temperature

1 Centro de Física de Materiales (CSIC, UPV/EHU) - Materials Physics Center, Paseo Manuel de Lardizabal 5, 20018 San Sebastián, Spain 2 Departamento de Física de Materiales, Universidad del País Vasco (UPV/EHU), Apartado 1072, 20800 San Sebastián, Spain 3 IKERBASQUE - Basque Foundation for Science, Alameda Urquijo 36, 48011 Bilbao, Spain
* Author to whom correspondence should be addressed.
Received: 1 September 2011 / Revised: 15 September 2011 / Accepted: 6 October 2011 / Published: 7 October 2011
(This article belongs to the Special Issue Click Chemistry in Polymer Science)
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“Click” chemistry has become an efficient avenue to unimolecular polymeric nanoparticles through the self-crosslinking of individual polymer chains containing appropriate functional groups. Herein we report the synthesis of ultra-small (7 nm in size) polymethyl methacrylate (PMMA) nanoparticles (NPs) by the “metal-free” cross-linking of PMMA-precursor chains prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization containing b-ketoester functional groups. Intramolecular collapse was performed by the one-pot reaction of b-ketoester moieties with alkyl diamines in tetrahydrofurane at r.t. (i.e., by enamine formation). The collapsing process was followed by size exclusion chromatography and by nuclear magnetic resonance spectroscopy. The size of the resulting PMMA-NPs was determined by dynamic light scattering. Enamine “click” chemistry increases the synthetic toolbox for the efficient synthesis of metal-free, ultra-small polymeric NPs.
Keywords: enamine “click” chemistry; intramolecular collapse; unimolecular polymeric nanoparticles enamine “click” chemistry; intramolecular collapse; unimolecular polymeric nanoparticles
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Buruaga, L.; Pomposo, J.A. Metal-Free Polymethyl Methacrylate (PMMA) Nanoparticles by Enamine “Click” Chemistry at Room Temperature. Polymers 2011, 3, 1673-1683.

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