Intelligent Polymeric Nanocarriers Responding to Physical or Biological Signals: A New Paradigm of Cytosolic Drug Delivery for Tumor Treatment
Abstract
:1. Introduction
2. Stimuli-Responsive Delivery Systems
2.1. Acidic pH-Activating Systems
Polymer | Description | Drug | Ref. |
---|---|---|---|
PolyHis-b-PEG | Protonation of the imidazole group in His block at lower pH (≤ pH 7.2), resulting drug release | DOX | [20] |
Blended polymers of polyHis-b-PEG-folate /PLLA-b-PEG-folate | Micelles were destabilized in the pH range of 7.2-6.6, resulting drug release | DOX | [28,29] |
Pullulan acetate and oligo-sulfadimethoxine (PA-g-OSDM) | Acid pH induced internal structural change, resulting drug release | DOX | [21] |
Poly[(L-histidine)-co-(L-phenyl alanine)]-b-PEG (HF-b-PEG) | Drug release by the micelle destabilization at tumor extracellular pH | DOX | [46] |
Poly(N-isopropylacrylamide) (PNIPAM) | A coil-to-globule transition at acidic pH was utilized to destabilize intracellular vehicle membrane | DOX | [47] |
Folate-PEG-b-poly(aspartate hydrazone doxorubicin) [Folate-PEG-b- poly(Asp-Hyd-DOX)] | Hydrazone bond between drug and polymer was cleaved intracellularly at low pH (5.5), resulting in drug release | DOX | [48] |
Poly(Ɛ-caprolactone-co-lactide)-b-PEG-b-poly(Ɛ-caprolactone-co-lactide) with sulfamethazine oligomer(OSM-PCLA-b-PEG-b-PCLA-OSM) | Rapid sol-to-gel transition with change in pH, resulting in triggering drug release | PTX | [49] |
Poly(N-isopropylacrylamide-cobutylmethacrylate-co-acrylic acid) | A pH-dependent drug release behavior was observed in the pH range of pH 5.0-6.0 | Insulin | [50] |
Enzyme-activated polymer | Enzymatic site | Drug | Ref. |
---|---|---|---|
N-(2-hydroxypropy1) methacrylamide-GFLG-mesochlorin e6 (HPMA-GFLG-Mce 6) | GFLG | Mce6 | [60] |
N-(2-hydroxypropy1) methacrylamide-GFLG- Geldanamycin (HPMA-GFLG-GDM) | GFLG | GDM | [62] |
Poly(ε-caprolactone)–b-poly(ethyl ethylene phosphate) | Disulfide bond | DOX | [84] |
PEG-b-poly(amidoamine) dendrimer- succinic acid-PTX | Ester bond | PTX | [89] |
Polyglycerol dendrimer- Ala-Phe-Lys-MTX | Ala-Phe-Lys | MTX | [90] |
Trimeric pro-drug (DOX/CPT/etoposide) | Aldol, Retro-aldol | DOX, CPT, etoposide | [91] |
Poly(γ-glutamic acid)-based nanoparticles (γ-PGA NPs) | Phenylalanine ethyl ester | OVA | [92] |
N-(2-hydroxypropyl) methacrylamide with methacryloylglycylglycine 4-nitrophenyl ester (PHPMA) | Ester bond | CPT | [63] |
2.1.1. Synthetic anticancer drug delivery
2.1.2. Protein drug delivery
2.2. Enzyme-Activating Systems
2.3. Temperature-Activating Systems
3. Conclusions
Acknowledgements
References
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Lee, B.R.; Baik, H.J.; Oh, N.M.; Lee, E.S. Intelligent Polymeric Nanocarriers Responding to Physical or Biological Signals: A New Paradigm of Cytosolic Drug Delivery for Tumor Treatment. Polymers 2010, 2, 86-101. https://doi.org/10.3390/polym2020086
Lee BR, Baik HJ, Oh NM, Lee ES. Intelligent Polymeric Nanocarriers Responding to Physical or Biological Signals: A New Paradigm of Cytosolic Drug Delivery for Tumor Treatment. Polymers. 2010; 2(2):86-101. https://doi.org/10.3390/polym2020086
Chicago/Turabian StyleLee, Bo Reum, Hye Jung Baik, Nam Muk Oh, and Eun Seong Lee. 2010. "Intelligent Polymeric Nanocarriers Responding to Physical or Biological Signals: A New Paradigm of Cytosolic Drug Delivery for Tumor Treatment" Polymers 2, no. 2: 86-101. https://doi.org/10.3390/polym2020086