Next Article in Journal
Review on the Functional Determinants and Durability of Shape Memory Polymers
Previous Article in Journal
Intelligent Polymeric Nanocarriers Responding to Physical or Biological Signals: A New Paradigm of Cytosolic Drug Delivery for Tumor Treatment
Polymers 2010, 2(3), 102-119; doi:10.3390/polym2030102
Article

Polyurethane Membranes Modified with Isopropyl Myristate as a Potential Candidate for Encapsulating Electronic Implants: A Study of Biocompatibility and Water Permeability

1,* , 1
, 1,2
, 1
, 3
, 1
 and 1
1 School of Engineering and Materials Science, Interdisciplinary Research Centre in Biomedical Materials, Queen Mary University of London, Mile End Road, London, E1 4NS, UK 2 Advanced Prosthodontics, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA, USA 3 Centre for Academic Surgery, Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, 4 Newark Street, London, E1 2AT, UK
* Author to whom correspondence should be addressed.
Received: 31 May 2010 / Revised: 8 July 2010 / Accepted: 8 July 2010 / Published: 12 July 2010
Download PDF [556 KB, 13 July 2010; original version 12 July 2010]

Abstract

Medical polyurethanes have shown good bio-stability and mechanical properties and have been used as coating for implantable medical devices. However, despite their excellent properties, they are relatively permeable to liquid water and water vapour which is a drawback for electronic implant encapsulation. In this study polyether polyurethanes with different soft segment molecular weights were modified by incorporating isopropyl myristate (IPM), as a hydrophobic modifying agent, and the effect of IPM on water resistant and biocompatibility of membranes were investigated. IPM changed the surface properties of the polyurethane film and reduced its surface energy. Polyurethane films were found to be stable with IPM concentrations of 1–5 wt% based upon their chemistry; however it leached out in BSA at higher concentrations. Though, low concentrations of IPM reduced both liquid water and water vapour permeability; at higher IPM content liquid permeability did not improved significantly. In general, the polyurethane materials showed much lower water permeability compared with currently used silicone packaging material for electronic implants. In addition, cytotoxicity assessment of IPM containing polyurethanes showed no evidence of cytotoxcity up to 5 wt% IPM.
Keywords: isopropyl myristate; polyurethane; implantable devices; biocompatibility; water permeability isopropyl myristate; polyurethane; implantable devices; biocompatibility; water permeability
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Export to BibTeX |
EndNote


MDPI and ACS Style

Roohpour, N.; Wasikiewicz, J.M.; Moshaverinia, A.; Paul, D.; Grahn, M.F.; Rehman, I.U.; Vadgama, P. Polyurethane Membranes Modified with Isopropyl Myristate as a Potential Candidate for Encapsulating Electronic Implants: A Study of Biocompatibility and Water Permeability. Polymers 2010, 2, 102-119.

View more citation formats

Article Metrics

Comments

Citing Articles

[Return to top]
Polymers EISSN 2073-4360 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert