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• Baik, H
• Oh, N
• Lee, E
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• Oh, N
• Lee, E
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• Baik, H
• Oh, N
• Lee, E

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Polymers 2010, 2(2), 86-101; doi:10.3390/polym2020086

Review

Intelligent Polymeric Nanocarriers Responding to Physical or Biological Signals: A New Paradigm of Cytosolic Drug Delivery for Tumor Treatment

Bo Reum Lee, Hye Jung Baik, Nam Muk Oh and Eun Seong Lee*

Division of Biotechnology, The Catholic University of Korea, 43-1 Yeokgok 2-dong, Wonmi-gu, Bucheon-si, Gyeonggi-do 420-743, Korea

* Author to whom correspondence should be addressed.

Received: 28 April 2010; in revised form: 2 June 2010 / Accepted: 18 June 2010 / Published: 22 June 2010

(This article belongs to the Special Issue Novel Stimuli-Responsive (co)Polymers)

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Abstract: The physicochemical properties of stimuli-responsive polymers change with physical or biological signals, such as pH, enzyme concentrations, and temperature. These polymers have attracted considerable attention in the field of drug delivery. The drug carrier system, which was revolutionized by the introduction of these polymers, has recently provided a new paradigm of maximizing the therapeutic activity of drugs. This review highlights recent studies regarding stimuli-responsive drug carriers tailor-made for effective cytosolic drug delivery, with particular emphasis on tumor treatment.

Keywords: stimuli-responsive polymer; cytosolic drug delivery; tumor treatment

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