Next Article in Journal
Polyurethane Membranes Modified with Isopropyl Myristate as a Potential Candidate for Encapsulating Electronic Implants: A Study of Biocompatibility and Water Permeability
Next Article in Special Issue
Review on the Functional Determinants and Durability of Shape Memory Polymers
Previous Article in Journal
Shape-Memory Properties of Segmented Polymers Containing Aramid Hard Segments and Polycaprolactone Soft Segments
Previous Article in Special Issue
Thermal-Mechanical Properties of Polyurethane-Clay Shape Memory Polymer Nanocomposites
Polymers 2010, 2(2), 86-101; doi:10.3390/polym2020086
Review

Intelligent Polymeric Nanocarriers Responding to Physical or Biological Signals: A New Paradigm of Cytosolic Drug Delivery for Tumor Treatment

, ,  and *
Division of Biotechnology, The Catholic University of Korea, 43-1 Yeokgok 2-dong, Wonmi-gu, Bucheon-si, Gyeonggi-do 420-743, Korea
* Author to whom correspondence should be addressed.
Received: 28 April 2010 / Revised: 2 June 2010 / Accepted: 18 June 2010 / Published: 22 June 2010
(This article belongs to the Special Issue Novel Stimuli-Responsive (co)Polymers)
Download PDF [664 KB, uploaded 22 June 2010]

Abstract

The physicochemical properties of stimuli-responsive polymers change with physical or biological signals, such as pH, enzyme concentrations, and temperature. These polymers have attracted considerable attention in the field of drug delivery. The drug carrier system, which was revolutionized by the introduction of these polymers, has recently provided a new paradigm of maximizing the therapeutic activity of drugs. This review highlights recent studies regarding stimuli-responsive drug carriers tailor-made for effective cytosolic drug delivery, with particular emphasis on tumor treatment.
Keywords: stimuli-responsive polymer; cytosolic drug delivery; tumor treatment stimuli-responsive polymer; cytosolic drug delivery; tumor treatment
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Lee, B.R.; Baik, H.J.; Oh, N.M.; Lee, E.S. Intelligent Polymeric Nanocarriers Responding to Physical or Biological Signals: A New Paradigm of Cytosolic Drug Delivery for Tumor Treatment. Polymers 2010, 2, 86-101.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Polymers EISSN 2073-4360 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert