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Polymers 2010, 2(2), 86-101; doi:10.3390/polym2020086

Intelligent Polymeric Nanocarriers Responding to Physical or Biological Signals: A New Paradigm of Cytosolic Drug Delivery for Tumor Treatment

Division of Biotechnology, The Catholic University of Korea, 43-1 Yeokgok 2-dong, Wonmi-gu, Bucheon-si, Gyeonggi-do 420-743, Korea
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Received: 28 April 2010 / Revised: 2 June 2010 / Accepted: 18 June 2010 / Published: 22 June 2010
(This article belongs to the Special Issue Novel Stimuli-Responsive (co)Polymers)
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Abstract

The physicochemical properties of stimuli-responsive polymers change with physical or biological signals, such as pH, enzyme concentrations, and temperature. These polymers have attracted considerable attention in the field of drug delivery. The drug carrier system, which was revolutionized by the introduction of these polymers, has recently provided a new paradigm of maximizing the therapeutic activity of drugs. This review highlights recent studies regarding stimuli-responsive drug carriers tailor-made for effective cytosolic drug delivery, with particular emphasis on tumor treatment. View Full-Text
Keywords: stimuli-responsive polymer; cytosolic drug delivery; tumor treatment stimuli-responsive polymer; cytosolic drug delivery; tumor treatment
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Lee, B.R.; Baik, H.J.; Oh, N.M.; Lee, E.S. Intelligent Polymeric Nanocarriers Responding to Physical or Biological Signals: A New Paradigm of Cytosolic Drug Delivery for Tumor Treatment. Polymers 2010, 2, 86-101.

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