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Polymers 2018, 10(6), 595; https://doi.org/10.3390/polym10060595

Dendritic Polyglycerol Sulfate for Therapy and Diagnostics

Institute for Chemistry and Biochemistry, Freie Universität Berlin, Takustraße 3, 14195 Berlin, Germany
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Received: 25 April 2018 / Revised: 22 May 2018 / Accepted: 26 May 2018 / Published: 29 May 2018
(This article belongs to the Special Issue Polymers for Therapy and Diagnostics)
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Abstract

Dendritic polyglycerol sulfate (dPGS) has originally been investigated as an anticoagulant to potentially substitute for the natural glycosaminoglycan heparin. Compared to unfractionated heparin, dPGS possesses lower anticoagulant activity but a much higher anticomplementary effect. Since coagulation, complement activation, and inflammation are often present in the pathophysiology of numerous diseases, dPGS polymers with both anticoagulant and anticomplementary activities represent promising candidates for the development of polymeric drugs of nanosized architecture. In this review, we describe the nanomedical applications of dPGS based on its anti-inflammatory activity. Furthermore, the application of dPGS as a carrier molecule for diagnostic molecules and therapeutic drugs is reviewed, based on the ability to target tumors and localize in tumor cells. Finally, the application of dPGS for inhibition of virus infections is described. View Full-Text
Keywords: dendritic polyglycerol; heparin; inflammation; targeting dendritic polyglycerol; heparin; inflammation; targeting
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Rades, N.; Licha, K.; Haag, R. Dendritic Polyglycerol Sulfate for Therapy and Diagnostics. Polymers 2018, 10, 595.

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