Next Article in Journal
Influence of Boron on Initial Austenite Grain Size and Hot Deformation Behavior of Boron Microalloyed Steels
Next Article in Special Issue
Crystal Structures, Thermal Analysis, and Dissolution Behavior of New Solid Forms of the Antiviral Drug Arbidol with Dicarboxylic Acids
Previous Article in Journal
Enthalpies of Formation of Transition Metal Diborides: A First Principles Study
Article Menu

Export Article

Open AccessArticle
Crystals 2015, 5(4), 583-591; doi:10.3390/cryst5040583

Liquid-Assisted Grinding to Prepare a Cocrystal of Adefovir Dipivoxil Thermodynamically Less Stable than Its Neat Phase

Department of Chemical Engineering, Soongsil University, Seoul 06978, Korea
Author to whom correspondence should be addressed.
Academic Editor: Sitaram Velaga
Received: 13 September 2015 / Revised: 25 October 2015 / Accepted: 12 November 2015 / Published: 19 November 2015
(This article belongs to the Special Issue Pharmaceutical Cocrystals)
View Full-Text   |   Download PDF [4672 KB, uploaded 19 November 2015]   |  


Liquid-assisted grinding was employed to generate a cocrystal of adefovir dipivoxil (AD) and glutaric acid (GLU), which had not been successfully obtained through solution crystallization. The cocrystal formation was confirmed with powder X-ray diffraction, and its thermal stability and release behavior were studied through differential scanning calorimetry and dissolution experiments, respectively. The AD/GLU cocrystal was less stable than neat AD phase and the previously reported AD cocrystals with other dicarboxylic acids, such as suberic acid and succinic acid. This suggests that the intermolecular interactions of the AD/GLU cocrystal are probably weaker than the other crystal phases. The release behavior of the AD/GLU was comparable with the cocrystal with suberic acid. The current study verifies the effectiveness of the liquid-assisted grinding for the preparation of the thermodynamically less stable cocrystal phase. View Full-Text
Keywords: cocrystal; grinding; adefovir dipivoxil; stability; release behavior cocrystal; grinding; adefovir dipivoxil; stability; release behavior

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Jung, S.; Choi, I.; Kim, I.W. Liquid-Assisted Grinding to Prepare a Cocrystal of Adefovir Dipivoxil Thermodynamically Less Stable than Its Neat Phase. Crystals 2015, 5, 583-591.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Crystals EISSN 2073-4352 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top