Crystals 2011, 1(3), 163-170; doi:10.3390/cryst1030163
Article

Crystal Structure of the N-Benzyloxycarbonyl-alanyl-phenylalanyl-methyl Ester: The Importance of the H-Bonding Pattern

1,* email, 2, 3 and 3,* email
Received: 15 July 2011; in revised form: 15 August 2011 / Accepted: 19 August 2011 / Published: 22 August 2011
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Large crystals of the methyl ester of the N-a-benzyloxycarbonyl protected Ala-Phe dipeptide (Z-AF-OMe) were obtained after the very slow evaporation of a solution of the corresponding carboxylic acid (Z-AF-OH) in methanol containing an excess of HCl. The structure was confirmed by single crystal X-ray diffraction data. It crystallizes in the orthorhombic space group P212121 with unit cell dimensions a = 5.0655(6) Å, b = 8.4614(8) Å, c = 46.856(5) Å, V = 2008.3(4) Å3, Z = 4. In the crystal, the molecules form hydrogen bonded chains running along the a axis of the unit cell. Other secondary interactions are also discussed.
Keywords: peptides; alanylphenylalanyl derivative; crystal structure; hydrogen bond
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MDPI and ACS Style

Alfonso, I.; Bolte, M.; Burguete, M.I.; Luis, S.V. Crystal Structure of the N-Benzyloxycarbonyl-alanyl-phenylalanyl-methyl Ester: The Importance of the H-Bonding Pattern. Crystals 2011, 1, 163-170.

AMA Style

Alfonso I, Bolte M, Burguete MI, Luis SV. Crystal Structure of the N-Benzyloxycarbonyl-alanyl-phenylalanyl-methyl Ester: The Importance of the H-Bonding Pattern. Crystals. 2011; 1(3):163-170.

Chicago/Turabian Style

Alfonso, Ignacio; Bolte, Michael; Burguete, M. Isabel; Luis, Santiago V. 2011. "Crystal Structure of the N-Benzyloxycarbonyl-alanyl-phenylalanyl-methyl Ester: The Importance of the H-Bonding Pattern." Crystals 1, no. 3: 163-170.

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