Next Article in Journal
Local Immune Responsiveness of Mice Bearing Premalignant Oral Lesions to PD-1 Antibody Treatment
Next Article in Special Issue
Promotion of Tumor Invasion by Tumor-Associated Macrophages: The Role of CSF-1-Activated Phosphatidylinositol 3 Kinase and Src Family Kinase Motility Signaling
Previous Article in Journal
A Novel Micro Cold Atmospheric Plasma Device for Glioblastoma Both In Vitro and In Vivo
Previous Article in Special Issue
Timp1 Promotes Cell Survival by Activating the PDK1 Signaling Pathway in Melanoma
Article Menu
Issue 6 (June) cover image

Export Article

Open AccessReview
Cancers 2017, 9(6), 60;

Towards Targeting PI3K-Dependent Regulation of Gene Expression in Brain Cancer

Department of Pathology, School of Biomedical Sciences, University of Melbourne, Parkville 3010, VIC, Australia
Academic Editor: Marco Falasca
Received: 3 May 2017 / Revised: 22 May 2017 / Accepted: 23 May 2017 / Published: 30 May 2017
(This article belongs to the Special Issue PI3K/PDK1/Akt Pathways in Cancer)
Full-Text   |   PDF [565 KB, uploaded 15 June 2017]   |  


The PI3K pathway is one of the most highly perturbed cell signaling pathways in human cancer, including the most common malignant brain tumors, gliomas, where either activating mutations of positive pathway effectors or loss/inactivation of pathway inhibitors occurs. Knowledge of the precise transcription factors modulated by PI3K in tumor cells remains elusive but there are numerous PI3K-responsive signaling factors, including kinases, which can activate many transcription factors. In the context of cancer, these transcription factors participate in the regulation of target genes expression networks to support cancer cell characteristics such as survival, proliferation, migration and differentiation. This review focuses on the role of PI3K signaling-regulated transcription in brain cancer cells from a series of recent investigations. A deeper understanding of this regulation is beginning to provide the hope of developing more sophisticated anti-cancer targeting approaches, where both upstream and downstream components of the PI3K pathway may be targeted by existing and novel drugs. View Full-Text
Keywords: PI3K; cell signaling; transcription factors; CREB; PTEN; NFkB PI3K; cell signaling; transcription factors; CREB; PTEN; NFkB

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Mantamadiotis, T. Towards Targeting PI3K-Dependent Regulation of Gene Expression in Brain Cancer. Cancers 2017, 9, 60.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top