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Cancers 2017, 9(3), 23; doi:10.3390/cancers9030023

Photodynamic Detection of Peritoneal Metastases Using 5-Aminolevulinic Acid (ALA)

1
NPO Organization to support Peritoneal Surface Malignancy Treatment, 510 Fukushima-Cho, Shimogyou-Ku, Kyoto 600-8189, Japan
2
Peritoneal Surface Malignancy Center, Kishiwada Tokushukai Hospital, 4-27-1 Kamori-Cho, Kishiwada City, Osaka 596-8522, Japan
3
Department of General Surgery, Kusatsu General Hospital, 1660 Yabase, Kusatsu City, Shiga 525-8585, Japan
4
Central Research Resource Center, Cancer Research Institute, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan
5
NPO HIPEC Istanbul, Guzelbahce Sokak No:15 Nisantasi, Istanbul 34367, Turkey
6
Department of Peritoneal Surface Oncology, Beijing Shijitan Hospital of Capital Medical University, Beijing 100038, China
7
Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsu-Cho, Midori-ku, Yokohama 226-8501, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Samuel C. Mok
Received: 1 February 2017 / Revised: 8 February 2017 / Accepted: 16 February 2017 / Published: 1 March 2017
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Abstract

In the past, peritoneal metastasis (PM) was considered as a terminal stage of cancer. From the early 1990s, however, a new comprehensive treatment consisting of cytoreductive surgery and perioperative chemotherapy has been established to improve long-term survival for selected patients with PM. Among prognostic indicators after the treatment, completeness of cytoreduction is the most independent predictors of survival. However, peritoneal recurrence is a main cause of recurrence, even after complete cytoreduction. As a cause of peritoneal recurrence, small PM may be overlooked at the time of cytoreductive surgery (CRS), therefore, development of a new method to detect small PM is desired. Recently, photodynamic diagnosis (PDD) was developed for detection of PM. The objectives of this review were to evaluate whether PDD using 5-aminolevulinic acid (ALA) could improve detection of small PM. View Full-Text
Keywords: aminolevulinic acid; photodynamic diagnosis (PDD); peritoneal surface malignancies; PEPT1; ABCG2; ferrochelatase aminolevulinic acid; photodynamic diagnosis (PDD); peritoneal surface malignancies; PEPT1; ABCG2; ferrochelatase
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Yonemura, Y.; Endo, Y.; Canbay, E.; Liu, Y.; Ishibashi, H.; Mizumoto, A.; Hirano, M.; Imazato, Y.; Takao, N.; Ichinose, M.; Noguchi, K.; Li, Y.; Wakama, S.; Yamada, K.; Hatano, K.; Shintani, H.; Yoshitake, H.; Ogura, S.-I. Photodynamic Detection of Peritoneal Metastases Using 5-Aminolevulinic Acid (ALA). Cancers 2017, 9, 23.

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