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Cancers 2017, 9(3), 23;

Photodynamic Detection of Peritoneal Metastases Using 5-Aminolevulinic Acid (ALA)

NPO Organization to support Peritoneal Surface Malignancy Treatment, 510 Fukushima-Cho, Shimogyou-Ku, Kyoto 600-8189, Japan
Peritoneal Surface Malignancy Center, Kishiwada Tokushukai Hospital, 4-27-1 Kamori-Cho, Kishiwada City, Osaka 596-8522, Japan
Department of General Surgery, Kusatsu General Hospital, 1660 Yabase, Kusatsu City, Shiga 525-8585, Japan
Central Research Resource Center, Cancer Research Institute, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan
NPO HIPEC Istanbul, Guzelbahce Sokak No:15 Nisantasi, Istanbul 34367, Turkey
Department of Peritoneal Surface Oncology, Beijing Shijitan Hospital of Capital Medical University, Beijing 100038, China
Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsu-Cho, Midori-ku, Yokohama 226-8501, Japan
Author to whom correspondence should be addressed.
Academic Editor: Samuel C. Mok
Received: 1 February 2017 / Revised: 8 February 2017 / Accepted: 16 February 2017 / Published: 1 March 2017
View Full-Text   |   Download PDF [2779 KB, uploaded 1 March 2017]   |  


In the past, peritoneal metastasis (PM) was considered as a terminal stage of cancer. From the early 1990s, however, a new comprehensive treatment consisting of cytoreductive surgery and perioperative chemotherapy has been established to improve long-term survival for selected patients with PM. Among prognostic indicators after the treatment, completeness of cytoreduction is the most independent predictors of survival. However, peritoneal recurrence is a main cause of recurrence, even after complete cytoreduction. As a cause of peritoneal recurrence, small PM may be overlooked at the time of cytoreductive surgery (CRS), therefore, development of a new method to detect small PM is desired. Recently, photodynamic diagnosis (PDD) was developed for detection of PM. The objectives of this review were to evaluate whether PDD using 5-aminolevulinic acid (ALA) could improve detection of small PM. View Full-Text
Keywords: aminolevulinic acid; photodynamic diagnosis (PDD); peritoneal surface malignancies; PEPT1; ABCG2; ferrochelatase aminolevulinic acid; photodynamic diagnosis (PDD); peritoneal surface malignancies; PEPT1; ABCG2; ferrochelatase

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Yonemura, Y.; Endo, Y.; Canbay, E.; Liu, Y.; Ishibashi, H.; Mizumoto, A.; Hirano, M.; Imazato, Y.; Takao, N.; Ichinose, M.; Noguchi, K.; Li, Y.; Wakama, S.; Yamada, K.; Hatano, K.; Shintani, H.; Yoshitake, H.; Ogura, S.-I. Photodynamic Detection of Peritoneal Metastases Using 5-Aminolevulinic Acid (ALA). Cancers 2017, 9, 23.

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