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Cancers 2017, 9(2), 16; doi:10.3390/cancers9020016

Epidermal Growth Factor Pathway Signaling in Drosophila Embryogenesis: Tools for Understanding Cancer

1
Division of Science, Yale-NUS College, Singapore 138527, Singapore
2
Department of Biological Science, National University of Singapore, Singapore 138615, Singapore
*
Author to whom correspondence should be addressed.
Academic Editor: Zhixiang Wang
Received: 14 December 2016 / Revised: 2 February 2017 / Accepted: 3 February 2017 / Published: 7 February 2017
(This article belongs to the Special Issue EGFR Family Signaling in Cancer)
View Full-Text   |   Download PDF [917 KB, uploaded 7 February 2017]   |  

Abstract

EGF signaling is a well-known oncogenic pathway in animals. It is also a key developmental pathway regulating terminal and dorsal-ventral patterning along with many other aspects of embryogenesis. In this review, we focus on the diverse roles for the EGF pathway in Drosophila embryogenesis. We review the existing body of evidence concerning EGF signaling in Drosophila embryogenesis focusing on current uncertainties in the field and areas for future study. This review provides a foundation for utilizing the Drosophila model system for research into EGF effects on cancer. View Full-Text
Keywords: EGF signaling; Drosophila development; RAS; RAF; MAP kinase; MEK EGF signaling; Drosophila development; RAS; RAF; MAP kinase; MEK
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Lusk, J.B.; Lam, V.Y.M.; Tolwinski, N.S. Epidermal Growth Factor Pathway Signaling in Drosophila Embryogenesis: Tools for Understanding Cancer. Cancers 2017, 9, 16.

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