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Cancers 2017, 9(1), 8; doi:10.3390/cancers9010008

Exosomes in Cancer Diagnostics

Department of Pathology, Stony Brook Medicine, 101 Nicolls Road, Stony Brook, NY 11794, USA
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Author to whom correspondence should be addressed.
Academic Editor: Samuel C. Mok
Received: 29 November 2016 / Revised: 6 January 2017 / Accepted: 9 January 2017 / Published: 12 January 2017
View Full-Text   |   Download PDF [220 KB, uploaded 12 January 2017]

Abstract

Exosomes are endosome derived extracellular vesicles of 30–120 nm size ranges. Exosomes have been identified as mediators of cell-to-cell communication by transferring bioactive molecules such as nucleic acids, proteins and lipids into recipient cells. While exosomes are secreted by multiple cell types, cancer derived exosomes not only influence the invasive potentials of proximally located cells, but also affect distantly located tissues. Based on their ability to alter tumor microenvironment by regulating immunity, angiogenesis and metastasis, there has been growing interest in defining the clinical relevance of exosomes in cancers. In particular, exosomes are valuable sources for biomarkers due to selective cargo loading and resemblance to their parental cells. In this review, we summarize the recent findings to utilize exosomes as cancer biomarkers for early detection, diagnosis and therapy selection. View Full-Text
Keywords: exosomes; cancer; biomarkers exosomes; cancer; biomarkers
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Soung, Y.H.; Ford, S.; Zhang, V.; Chung, J. Exosomes in Cancer Diagnostics. Cancers 2017, 9, 8.

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