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Cancers 2016, 8(12), 107; doi:10.3390/cancers8120107

Ligand Activation of TAM Family Receptors-Implications for Tumor Biology and Therapeutic Response

Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ 07103, USA
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Academic Editors: Deric L. Wheeler and Toni M. Brand
Received: 17 September 2016 / Revised: 16 November 2016 / Accepted: 26 November 2016 / Published: 29 November 2016
(This article belongs to the Special Issue TAM family receptors in cancer biology and therapeutic resistance)
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Abstract

The TAM family of receptors (i.e., Tyro3, Axl, and Mertk), and their ligands Growth arrest specific factor 6 (Gas6) and Protein S (Pros1) contribute to several oncogenic processes, such as cell survival, invasion, migration, chemo-resistance, and metastasis, whereby expression often correlates with poor clinical outcomes. In recent years, there has been great interest in the study of TAM receptors in cancer, stemming both from their roles as oncogenic signaling receptors, as well as their roles in tumor immunology. As a result, several classes of TAM inhibitors that include small molecule tyrosine kinase inhibitors, monoclonal antibodies, decoy receptors, as well as novel strategies to target TAM ligands are being developed. This paper will review the biology of TAM receptors and their ligands with a focus on cancer, as well as evidence-based data for the continued pursuit of TAM/Gas6 inhibitors in clinical practice. View Full-Text
Keywords: Tyro3; Axl; Mertk; Gas6; protein S; immune evasion; tumor microenvironment Tyro3; Axl; Mertk; Gas6; protein S; immune evasion; tumor microenvironment
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Davra, V.; Kimani, S.G.; Calianese, D.; Birge, R.B. Ligand Activation of TAM Family Receptors-Implications for Tumor Biology and Therapeutic Response. Cancers 2016, 8, 107.

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