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Cancers 2016, 8(10), 95; doi:10.3390/cancers8100095

Functional Roles of E6 and E7 Oncoproteins in HPV-Induced Malignancies at Diverse Anatomical Sites

1
International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I-34149 Trieste, Italy
2
Division of Molecular Medicine, Rudjer Boskovic Institute, 10000 Zagreb, Croatia
Academic Editor: Samuel C. Mok
Received: 30 June 2016 / Revised: 15 September 2016 / Accepted: 8 October 2016 / Published: 19 October 2016
(This article belongs to the Special Issue HPV Associated Cancers)
View Full-Text   |   Download PDF [1542 KB, uploaded 19 October 2016]   |  

Abstract

Approximately 200 human papillomaviruses (HPVs) infect human epithelial cells, of which the alpha and beta types have been the most extensively studied. Alpha HPV types mainly infect mucosal epithelia and a small group of these causes over 600,000 cancers per year worldwide at various anatomical sites, especially anogenital and head-and-neck cancers. Of these the most important is cervical cancer, which is the leading cause of cancer-related death in women in many parts of the world. Beta HPV types infect cutaneous epithelia and may contribute towards the initiation of non-melanoma skin cancers. HPVs encode two oncoproteins, E6 and E7, which are directly responsible for the development of HPV-induced carcinogenesis. They do this cooperatively by targeting diverse cellular pathways involved in the regulation of cell cycle control, of apoptosis and of cell polarity control networks. In this review, the biological consequences of papillomavirus targeting of various cellular substrates at diverse anatomical sites in the development of HPV-induced malignancies are highlighted. View Full-Text
Keywords: HPV; cancer; E6 and E7 oncoproteins HPV; cancer; E6 and E7 oncoproteins
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Tomaić, V. Functional Roles of E6 and E7 Oncoproteins in HPV-Induced Malignancies at Diverse Anatomical Sites. Cancers 2016, 8, 95.

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