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Cancers 2015, 7(4), 2134-2146; doi:10.3390/cancers7040882

Roles of TRPM8 Ion Channels in Cancer: Proliferation, Survival, and Invasion

1
Division of Hematology-Oncology, Department of Medicine, Penn State College of Medicine, Pennsylvania State University, Hershey, PA 17033, USA
2
Program of Experimental Therapeutics, Penn State Hershey Cancer Institute, Pennsylvania State University, Hershey, PA 17033, USA
3
Penn State Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, PA 17033, USA
Academic Editor: Vita Golubovskaya
Received: 13 June 2015 / Revised: 15 October 2015 / Accepted: 15 October 2015 / Published: 23 October 2015
(This article belongs to the Special Issue Cancer Cell Proliferation)
View Full-Text   |   Download PDF [599 KB, uploaded 23 October 2015]   |  

Abstract

The goal of this article is to provide a critical review of the transient receptor potential melastatin-subfamily member 8 (TRPM8) in cancers, with an emphasis on its roles in cellular proliferation, survival, and invasion. The TRPM8 ion channels regulate Ca²⁺ homeostasis and function as a cellular sensor and transducer of cold temperature. Accumulating evidence has demonstrated that TRPM8 is aberrantly expressed in a variety of malignant solid tumors. Clinicopathological analysis has shown that over-expression of TRPM8 correlates with tumor progression. Experimental data have revealed important roles of TRPM8 channels in cancer cells proliferation, survival, and invasion, which appear to be dependent on the cancer type. Recent reports have begun to reveal the signaling mechanisms that mediate the biological roles of TRPM8 in tumor growth and metastasis. Determining the mechanistic roles of TRPM8 in cancer is expected to elucidate the impact of thermal and chemical stimuli on the formation and progression of neoplasms. Translational research and clinical investigation of TRPM8 in malignant diseases will help exploit these ion channels as molecular biomarkers and therapeutic targets for developing precision cancer medicine. View Full-Text
Keywords: calcium; cancer; cell cycle; ion channels; invasion; proliferation; senescence; survival; TRPM8 calcium; cancer; cell cycle; ion channels; invasion; proliferation; senescence; survival; TRPM8
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Yee, N.S. Roles of TRPM8 Ion Channels in Cancer: Proliferation, Survival, and Invasion. Cancers 2015, 7, 2134-2146.

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