Pathologic Cellular Events in Smoking-Related Pancreatitis
AbstractPancreatitis, a debilitating inflammatory disorder, results from pancreatic injury. Alcohol abuse is the foremost cause, although cigarette smoking has recently surfaced as a distinct risk factor. The mechanisms by which cigarette smoke and its toxins initiate pathological cellular events leading to pancreatitis, have not been clearly defined. Although cigarette smoke is composed of more than 4000 compounds, it is mainly nicotine and the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), which have been extensively studied with respect to pancreatic diseases. This review summarizes these research findings and highlights cellular pathways which may be of relevance in initiation and progression of smoking-related pancreatitis. View Full-Text
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Thrower, E. Pathologic Cellular Events in Smoking-Related Pancreatitis. Cancers 2015, 7, 723-735.
Thrower E. Pathologic Cellular Events in Smoking-Related Pancreatitis. Cancers. 2015; 7(2):723-735.Chicago/Turabian Style
Thrower, Edwin. 2015. "Pathologic Cellular Events in Smoking-Related Pancreatitis." Cancers 7, no. 2: 723-735.