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Cancers 2015, 7(2), 1005-1021; doi:10.3390/cancers7020821

Sarcoidosis in Melanoma Patients: Case Report and Literature Review

1,†,* and 2,†,*
1
School of Allied Health Sciences, University of Nevada, Las Vegas, 1060 Wiegand Road, Encinitas, CA 92024, USA
2
Department of Dermatology, University of California San Diego, 10991 Twinleaf Court, San Diego, CA 92131, USA
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Chyi-Chia Richard Lee
Received: 5 May 2015 / Accepted: 10 June 2015 / Published: 15 June 2015
(This article belongs to the Special Issue Current Topics in Cutaneous Melanoma)
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Abstract

Sarcoidosis is a systemic inflammatory disease characterized by the development of noncaseating granulomas in multiple organ systems. Many hematologic malignancies and solid tumors, including melanoma, have been associated with sarcoidosis. We describe the clinical and pathologic findings of a 54-year-old man with melanoma-associated sarcoidosis. In addition, we not only review the literature describing characteristics of other melanoma patients with sarcoidosis, but also the features of melanoma patients with antineoplastic therapy-associated sarcoidosis. Sarcoidosis has been described in 80 melanoma patients; sufficient information for analysis was provided in 39 of these individuals. In 43.6% of individuals (17 out of 39), sarcoidosis was directly associated with melanoma; in 56.4% of oncologic patients (22 out of 39), sarcoidosis was induced by antineoplastic therapy that had been administered for the treatment of their metastatic melanoma. The discovery of melanoma preceded the development of sarcoidosis in 12 of the 17 (70.5%) individuals who did not receive systemic treatment. Pulmonary and/or cutaneous manifestations of sarcoidosis were common among both groups of patients. Most patients did not require treatment for sarcoidosis. Melanoma patients—either following antineoplastic therapy or without systemic treatment—may be at an increased risk to develop sarcoidosis. In antineoplastic therapy naive melanoma patients, a common etiologic factor—such as exposure to ultraviolet light—may play a role in their developing melanoma and sarcoidosis. View Full-Text
Keywords: cancer; cutaneous; malignancy; melanoma; sarcoid; sarcoidosis; solid tumors cancer; cutaneous; malignancy; melanoma; sarcoid; sarcoidosis; solid tumors
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Beutler, B.D.; Cohen, P.R. Sarcoidosis in Melanoma Patients: Case Report and Literature Review. Cancers 2015, 7, 1005-1021.

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