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Cancers 2014, 6(3), 1691-1704; doi:10.3390/cancers6031691

Oral Human Papillomavirus (HPV) Infection among Unvaccinated High-Risk Young Adults

1
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
2
Baltimore County Health Department, Baltimore, MD 21212, USA
3
Ohio State University Comprehensive Cancer Center, Columbus, OH 43202, USA
*
Author to whom correspondence should be addressed.
Received: 20 June 2014 / Revised: 24 July 2014 / Accepted: 6 August 2014 / Published: 14 August 2014
(This article belongs to the Special Issue DNA Viruses in Human Cancer)
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Abstract

Oral HPV infection, the cause of most oropharyngeal cancer in the U.S., is not well studied among high-risk young adults. Men (n = 340) and women (n = 270) aged 18–25 years attending Baltimore County STD clinics were recruited if they declined HPV vaccination. Each participant had a 30-second oral rinse and gargle sample tested for 37 types of HPV DNA, and a risk-factor survey. Factors associated with prevalent infection were explored using log binomial regression. Men had higher prevalence of any oral HPV (15.3% vs. 7.8%, p = 0.004) and vaccine-type oral HPV (i.e., HPV16/18/6/11: 5.0% vs. 1.1%, p = 0.007) infection than women. In multivariate analysis, male gender (aPR = 1.93, 95% CI = 1.10–3.39), number of recent oral sex partners (p-trend = 0.013) and having ever performed oral sex on a woman (aPR = 1.73, 95% CI = 1.06–2.82) were associated with increased oral HPV prevalence. Performing oral sex on a woman may confer higher risk of oral HPV acquisition than performing oral sex on a man. View Full-Text
Keywords: oral HPV; young adults; STD clinic; gender oral HPV; young adults; STD clinic; gender
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

D'Souza, G.; Kluz, N.; Wentz, A.; Youngfellow, R.M.; Griffioen, A.; Stammer, E.; Guo, Y.; Xiao, W.; Gillison, M.L. Oral Human Papillomavirus (HPV) Infection among Unvaccinated High-Risk Young Adults. Cancers 2014, 6, 1691-1704.

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