Oral Human Papillomavirus (HPV) Infection among Unvaccinated High-Risk Young Adults
AbstractOral HPV infection, the cause of most oropharyngeal cancer in the U.S., is not well studied among high-risk young adults. Men (n = 340) and women (n = 270) aged 18–25 years attending Baltimore County STD clinics were recruited if they declined HPV vaccination. Each participant had a 30-second oral rinse and gargle sample tested for 37 types of HPV DNA, and a risk-factor survey. Factors associated with prevalent infection were explored using log binomial regression. Men had higher prevalence of any oral HPV (15.3% vs. 7.8%, p = 0.004) and vaccine-type oral HPV (i.e., HPV16/18/6/11: 5.0% vs. 1.1%, p = 0.007) infection than women. In multivariate analysis, male gender (aPR = 1.93, 95% CI = 1.10–3.39), number of recent oral sex partners (p-trend = 0.013) and having ever performed oral sex on a woman (aPR = 1.73, 95% CI = 1.06–2.82) were associated with increased oral HPV prevalence. Performing oral sex on a woman may confer higher risk of oral HPV acquisition than performing oral sex on a man. View Full-Text
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D'Souza, G.; Kluz, N.; Wentz, A.; Youngfellow, R.M.; Griffioen, A.; Stammer, E.; Guo, Y.; Xiao, W.; Gillison, M.L. Oral Human Papillomavirus (HPV) Infection among Unvaccinated High-Risk Young Adults. Cancers 2014, 6, 1691-1704.
D'Souza G, Kluz N, Wentz A, Youngfellow RM, Griffioen A, Stammer E, Guo Y, Xiao W, Gillison ML. Oral Human Papillomavirus (HPV) Infection among Unvaccinated High-Risk Young Adults. Cancers. 2014; 6(3):1691-1704.Chicago/Turabian Style
D'Souza, Gypsyamber; Kluz, Nicole; Wentz, Alicia; Youngfellow, Renee M.; Griffioen, Anne; Stammer, Emily; Guo, Yingshi; Xiao, Weihong; Gillison, Maura L. 2014. "Oral Human Papillomavirus (HPV) Infection among Unvaccinated High-Risk Young Adults." Cancers 6, no. 3: 1691-1704.