Next Article in Journal / Special Issue
Human Papillomavirus in Head and Neck Cancer
Previous Article in Journal
Tumor-Associated Macrophages as Major Players in the Tumor Microenvironment
Previous Article in Special Issue
Epstein-Barr Virus-Encoded RNAs: Key Molecules in Viral Pathogenesis
Article Menu

Export Article

Open AccessArticle
Cancers 2014, 6(3), 1691-1704;

Oral Human Papillomavirus (HPV) Infection among Unvaccinated High-Risk Young Adults

Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Baltimore County Health Department, Baltimore, MD 21212, USA
Ohio State University Comprehensive Cancer Center, Columbus, OH 43202, USA
Author to whom correspondence should be addressed.
Received: 20 June 2014 / Revised: 24 July 2014 / Accepted: 6 August 2014 / Published: 14 August 2014
(This article belongs to the Special Issue DNA Viruses in Human Cancer)
Full-Text   |   PDF [918 KB, uploaded 14 August 2014]


Oral HPV infection, the cause of most oropharyngeal cancer in the U.S., is not well studied among high-risk young adults. Men (n = 340) and women (n = 270) aged 18–25 years attending Baltimore County STD clinics were recruited if they declined HPV vaccination. Each participant had a 30-second oral rinse and gargle sample tested for 37 types of HPV DNA, and a risk-factor survey. Factors associated with prevalent infection were explored using log binomial regression. Men had higher prevalence of any oral HPV (15.3% vs. 7.8%, p = 0.004) and vaccine-type oral HPV (i.e., HPV16/18/6/11: 5.0% vs. 1.1%, p = 0.007) infection than women. In multivariate analysis, male gender (aPR = 1.93, 95% CI = 1.10–3.39), number of recent oral sex partners (p-trend = 0.013) and having ever performed oral sex on a woman (aPR = 1.73, 95% CI = 1.06–2.82) were associated with increased oral HPV prevalence. Performing oral sex on a woman may confer higher risk of oral HPV acquisition than performing oral sex on a man. View Full-Text
Keywords: oral HPV; young adults; STD clinic; gender oral HPV; young adults; STD clinic; gender
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

D'Souza, G.; Kluz, N.; Wentz, A.; Youngfellow, R.M.; Griffioen, A.; Stammer, E.; Guo, Y.; Xiao, W.; Gillison, M.L. Oral Human Papillomavirus (HPV) Infection among Unvaccinated High-Risk Young Adults. Cancers 2014, 6, 1691-1704.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top