Cancers 2014, 6(2), 723-740; doi:10.3390/cancers6020723
Review

Reciprocal Supportive Interplay between Glioblastoma and Tumor-Associated Macrophages

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Received: 13 February 2014; in revised form: 13 March 2014 / Accepted: 14 March 2014 / Published: 26 March 2014
(This article belongs to the Special Issue Glioblastoma)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Glioblastoma multiforme (GBM) is the most lethal and aggressive type of primary brain malignancy. Failures of the traditional therapies in treating GBMs raise the urgent requirement to develop new approaches with more responsive targets. The phenomenon of the high infiltration of tumor-associated macrophages (TAMs) into GBMs has been observed for a long time. Regardless of the limited knowledge about TAMs, the high percentage of supportive TAM in GBM tumor mass makes it possible to be a good target for GBM treatment. In this review, we discussed the unique features of TAMs in GBMs, including their origin, the tumor-supportive properties, the secreted cytokines, and the relevant mechanisms. In addition, we tried to interpret the current understandings about the interplay between GBM cancer cells and TAMs. Finally, the translational studies of targeting TAMs were also described.
Keywords: glioblastoma multiforme (GBM); tumor-associated macrophage (TAM); infiltration; microglia; immune therapy
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MDPI and ACS Style

Zhou, W.; Bao, S. Reciprocal Supportive Interplay between Glioblastoma and Tumor-Associated Macrophages. Cancers 2014, 6, 723-740.

AMA Style

Zhou W, Bao S. Reciprocal Supportive Interplay between Glioblastoma and Tumor-Associated Macrophages. Cancers. 2014; 6(2):723-740.

Chicago/Turabian Style

Zhou, Wenchao; Bao, Shideng. 2014. "Reciprocal Supportive Interplay between Glioblastoma and Tumor-Associated Macrophages." Cancers 6, no. 2: 723-740.

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