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Long Non-Coding RNAs Embedded in the Rb and p53 Pathways
Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 16 October 2013; in revised form: 12 November 2013 / Accepted: 20 November 2013 / Published: 4 December 2013
Abstract: In recent years, long non-coding RNAs (lncRNAs) have gained significant attention as a novel class of gene regulators. Although a small number of lncRNAs have been shown to regulate gene expression through diverse mechanisms including transcriptional regulation, mRNA splicing and translation, the physiological function and mechanism of action of the vast majority are not known. Profiling studies in cell lines and tumor samples have suggested a potential role of lncRNAs in cancer. Indeed, distinct lncRNAs have been shown to be embedded in the p53 and Rb networks, two of the major tumor suppressor pathways that control cell cycle progression and survival. Given the fact that inactivation of Rb and p53 is a hallmark of human cancer, in this review we discuss recent evidence on the function of lncRNAs in the Rb and p53 signaling pathways.
Keywords: cell cycle; lncRNA; miRNA; p53; Rb
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Subramanian, M.; Jones, M.F.; Lal, A. Long Non-Coding RNAs Embedded in the Rb and p53 Pathways. Cancers 2013, 5, 1655-1675.
Subramanian M, Jones MF, Lal A. Long Non-Coding RNAs Embedded in the Rb and p53 Pathways. Cancers. 2013; 5(4):1655-1675.
Subramanian, Murugan; Jones, Matthew F.; Lal, Ashish. 2013. "Long Non-Coding RNAs Embedded in the Rb and p53 Pathways." Cancers 5, no. 4: 1655-1675.