Next Article in Journal
Heterogeneity of Mesenchymal Markers Expression—Molecular Profiles of Cancer Cells Disseminated by Lymphatic and Hematogenous Routes in Breast Cancer
Next Article in Special Issue
Glioblastoma Multiforme: A Look Inside Its Heterogeneous Nature
Previous Article in Journal / Special Issue
Bevacizumab for Glioblastoma—A Promising Drug or Not?
Article Menu

Export Article

Open AccessReview
Cancers 2013, 5(4), 1469-1484; doi:10.3390/cancers5041469

Tumor Metabolism of Malignant Gliomas

Department of Radiation Oncology, Ohio State University Comprehensive Cancer Center & Arthur G James Cancer Hospital, Columbus, OH 43012, USA
*
Author to whom correspondence should be addressed.
Received: 22 October 2013 / Accepted: 24 October 2013 / Published: 8 November 2013
(This article belongs to the Special Issue Glioblastoma)
View Full-Text   |   Download PDF [530 KB, uploaded 8 November 2013]   |  

Abstract

Constitutively activated oncogenic signaling via genetic mutations such as in the EGFR/PI3K/Akt and Ras/RAF/MEK pathways has been recognized as a major driver for tumorigenesis in most cancers. Recent insights into tumor metabolism have further revealed that oncogenic signaling pathways directly promote metabolic reprogramming to upregulate biosynthesis of lipids, carbohydrates, protein, DNA and RNA, leading to enhanced growth of human tumors. Therefore, targeting cell metabolism has become a novel direction for drug development in oncology. In malignant gliomas, metabolism pathways of glucose, glutamine and lipid are significantly reprogrammed. Moreover, molecular mechanisms causing these metabolic changes are just starting to be unraveled. In this review, we will summarize recent studies revealing critical gene alterations that lead to metabolic changes in malignant gliomas, and also discuss promising therapeutic strategies via targeting the key players in metabolic regulation. View Full-Text
Keywords: glioblastoma; tumor metabolism; SREBP-1; LDLR; LXR; glucose; lipids; cholesterol glioblastoma; tumor metabolism; SREBP-1; LDLR; LXR; glucose; lipids; cholesterol
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Ru, P.; Williams, T.M.; Chakravarti, A.; Guo, D. Tumor Metabolism of Malignant Gliomas. Cancers 2013, 5, 1469-1484.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top