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Epigenetics and Colorectal Cancer Pathogenesis
Cancers 2013, 5(3), 786-814; doi:10.3390/cancers5030786
Review

Alterations of 5-Hydroxymethylcytosine in Human Cancers

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Received: 26 March 2013; in revised form: 16 May 2013 / Accepted: 29 May 2013 / Published: 25 June 2013
(This article belongs to the Special Issue Cancer Epigenetics)
View Full-Text   |   Download PDF [1678 KB, uploaded 25 June 2013]   |   Browse Figures
Abstract: Prior to 2009, 5-methylcytosine (5-mC) was thought to be the only biologically significant cytosine modification in mammalian DNA. With the discovery of the TET enzymes, which convert 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC), however, intense interest has emerged in determining the biological function of 5-hmC. Here, we review the techniques used to study 5-hmC and evidence that alterations to 5-hmC physiology play a functional role in the molecular pathogenesis of human cancers.
Keywords: 5-hydroxymethylcytosine; 5-methylcytosine; cancer; DNA methylation; epigenetics; ten-eleven translocation; TET 5-hydroxymethylcytosine; 5-methylcytosine; cancer; DNA methylation; epigenetics; ten-eleven translocation; TET
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Mariani, C.J.; Madzo, J.; Moen, E.L.; Yesilkanal, A.; Godley, L.A. Alterations of 5-Hydroxymethylcytosine in Human Cancers. Cancers 2013, 5, 786-814.

AMA Style

Mariani CJ, Madzo J, Moen EL, Yesilkanal A, Godley LA. Alterations of 5-Hydroxymethylcytosine in Human Cancers. Cancers. 2013; 5(3):786-814.

Chicago/Turabian Style

Mariani, Christopher J.; Madzo, Jozef; Moen, Erika L.; Yesilkanal, Ali; Godley, Lucy A. 2013. "Alterations of 5-Hydroxymethylcytosine in Human Cancers." Cancers 5, no. 3: 786-814.


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