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Alterations of 5-Hydroxymethylcytosine in Human Cancers
AbstractPrior to 2009, 5-methylcytosine (5-mC) was thought to be the only biologically significant cytosine modification in mammalian DNA. With the discovery of the TET enzymes, which convert 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC), however, intense interest has emerged in determining the biological function of 5-hmC. Here, we review the techniques used to study 5-hmC and evidence that alterations to 5-hmC physiology play a functional role in the molecular pathogenesis of human cancers.
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Mariani, C.J.; Madzo, J.; Moen, E.L.; Yesilkanal, A.; Godley, L.A. Alterations of 5-Hydroxymethylcytosine in Human Cancers. Cancers 2013, 5, 786-814.View more citation formats
Mariani CJ, Madzo J, Moen EL, Yesilkanal A, Godley LA. Alterations of 5-Hydroxymethylcytosine in Human Cancers. Cancers. 2013; 5(3):786-814.Chicago/Turabian Style
Mariani, Christopher J.; Madzo, Jozef; Moen, Erika L.; Yesilkanal, Ali; Godley, Lucy A. 2013. "Alterations of 5-Hydroxymethylcytosine in Human Cancers." Cancers 5, no. 3: 786-814.