Cancers 2013, 5(3), 786-814; doi:10.3390/cancers5030786
Review

Alterations of 5-Hydroxymethylcytosine in Human Cancers

1 Section of Hematology/Oncology, Department of Medicine, The University of Chicago, 5841 S. Maryland Ave., MC 2115, Chicago, IL 60637, USA 2 Committee on Molecular Pathogenesis and Molecular Medicine, The University of Chicago, Chicago, IL 60637, USA 3 Committee on Cancer Biology, The University of Chicago, Chicago, IL 60637, USA
* Author to whom correspondence should be addressed.
Received: 26 March 2013; in revised form: 16 May 2013 / Accepted: 29 May 2013 / Published: 25 June 2013
(This article belongs to the Special Issue Cancer Epigenetics)
PDF Full-text Download PDF Full-Text [1678 KB, uploaded 25 June 2013 11:59 CEST]
Abstract: Prior to 2009, 5-methylcytosine (5-mC) was thought to be the only biologically significant cytosine modification in mammalian DNA. With the discovery of the TET enzymes, which convert 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC), however, intense interest has emerged in determining the biological function of 5-hmC. Here, we review the techniques used to study 5-hmC and evidence that alterations to 5-hmC physiology play a functional role in the molecular pathogenesis of human cancers.
Keywords: 5-hydroxymethylcytosine; 5-methylcytosine; cancer; DNA methylation; epigenetics; ten-eleven translocation; TET

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Mariani, C.J.; Madzo, J.; Moen, E.L.; Yesilkanal, A.; Godley, L.A. Alterations of 5-Hydroxymethylcytosine in Human Cancers. Cancers 2013, 5, 786-814.

AMA Style

Mariani CJ, Madzo J, Moen EL, Yesilkanal A, Godley LA. Alterations of 5-Hydroxymethylcytosine in Human Cancers. Cancers. 2013; 5(3):786-814.

Chicago/Turabian Style

Mariani, Christopher J.; Madzo, Jozef; Moen, Erika L.; Yesilkanal, Ali; Godley, Lucy A. 2013. "Alterations of 5-Hydroxymethylcytosine in Human Cancers." Cancers 5, no. 3: 786-814.

Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert