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Cancers 2012, 4(2), 549-565; doi:10.3390/cancers4020549
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Potentiality and Boundaries of Use of Sorafenib in Patients with Hepatocellular Carcinoma: Awaiting the Results of Ongoing Clinical Trials

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 and
1,*
1 Clinical Trials Unit, National Cancer Institute—“G. Pascale” Foundation, via Mariano Semmola, Napoli 80131, Italy 2 Medical Statistics, Second University, v. L. Armanni 5, Napoli 80138, Italy 3 Medical Oncology Unit, “G.Rummo” Hospital, Benevento 82100, Italy
* Author to whom correspondence should be addressed.
Received: 8 May 2012 / Revised: 25 May 2012 / Accepted: 30 May 2012 / Published: 5 June 2012
(This article belongs to the Special Issue Advances and Research Progress in Hepatocellular Carcinoma)
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Abstract

No systemic therapy had been proven effective in patients with advanced hepatocellular carcinoma (HCC) until 2007, when a large randomized trial with sorafenib demonstrated a clinically relevant prolongation of survival. Currently, sorafenib represents standard treatment for patients with advanced HCC and well-preserved liver function, whilst the evidence about its effectiveness in patients with more severe liver impairment is less robust. A randomized trial to demonstrate the efficacy of sorafenib in Child-Pugh B patients with advanced HCC is currently ongoing. In the meantime, several trials are testing the role of sorafenib in early HCC (as adjuvant treatment after potentially curative loco-regional therapies) and in intermediate stage (exploring different modalities of integration of sorafenib with trans-arterial chemo-embolization). The results of all these trials will better define the potentiality and the boundaries of use of sorafenib in HCC patients.
Keywords: hepatocellular carcinoma; sorafenib; Child-Pugh B patients; trans-arterial chemo-embolization hepatocellular carcinoma; sorafenib; Child-Pugh B patients; trans-arterial chemo-embolization
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Di Maio, M.; Daniele, G.; Piccirillo, M.C.; Giordano, P.; Signoriello, G.; Daniele, B.; Perrone, F. Potentiality and Boundaries of Use of Sorafenib in Patients with Hepatocellular Carcinoma: Awaiting the Results of Ongoing Clinical Trials. Cancers 2012, 4, 549-565.

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