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Immunotherapy for Urothelial Carcinoma: Current Status and Perspectives
Department of Urology, Sapporo Medical University School of Medicine, South 1 West 16, Chuo-ku, Sapporo 060-8543, Japan
* Author to whom correspondence should be addressed.
Received: 7 June 2011; in revised form: 22 July 2011 / Accepted: 26 July 2011 / Published: 29 July 2011
Abstract: Intravesical instillation of bacillus Calmette Guérin (BCG) for the treatment of urothelial carcinoma (UC) of the bladder is based on the BCG-induced immune response, which eradicates and prevents bladder cancer. The results of recent studies have suggested that not only major histocompatibility complex (MHC)-nonrestricted immune cells such as natural killer cells, macrophages, neutrophils, etc., but also MHC-restricted CD8+ T cells play an important role and are one of the main effectors in this therapy. Better understanding of the mechanism of BCG immunotherapy supports the idea that active immunotherapy through its augmented T cell response can have great potential for the treatment of advanced UC. In this review, progress in immunotherapy for UC is discussed based on data from basic, translational and clinical studies. We also review the escape mechanism of cancer cells from the immune system, and down-regulation of MHC class I molecules.
Keywords: immunotherapy; urothelial cancer; cancer vaccine
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Cite This Article
MDPI and ACS Style
Kitamura, H.; Tsukamoto, T. Immunotherapy for Urothelial Carcinoma: Current Status and Perspectives. Cancers 2011, 3, 3055-3072.
Kitamura H, Tsukamoto T. Immunotherapy for Urothelial Carcinoma: Current Status and Perspectives. Cancers. 2011; 3(3):3055-3072.
Kitamura, Hiroshi; Tsukamoto, Taiji. 2011. "Immunotherapy for Urothelial Carcinoma: Current Status and Perspectives." Cancers 3, no. 3: 3055-3072.