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Cancers 2011, 3(2), 2214-2222; doi:10.3390/cancers3022214
Review

Cell Autonomous and Non-Autonomous Functions of IKKβ and NF-κB during the Pathogenesis of Gastrointestinal Tumors

 and *
Received: 6 February 2011; in revised form: 4 April 2011 / Accepted: 14 April 2011 / Published: 28 April 2011
(This article belongs to the Special Issue Cancer Diagnosis and Targeted Therapy)
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Abstract: Genetic studies describing a link between cancer and inflammation have increased recently. Activation of the transcription factor nuclear factor-κB (NF-κB) and its effector pathways has been proposed to be the missing link between these two processes. NF-κB is persistently activated in several types of tumors. However, NF-κB has a distinct role in cancer cells and in inflammatory cells. While in tumor cells NF-κB controls cell survival, in inflammatory cells NF-κB activates genes that encode pro-inflammatory cytokines which further act in a paracrine manner within the tumor microenvironment to contribute to tumorigenesis. Inactivation of NF-κB can also reduce chemoresistance and radioresistance of cancer cells. Therefore, specific NF-κB inhibition in combination with cytotoxic drugs and/or irradiation represents a very promising strategy for cancer therapy.
Keywords: NF-κB; inflammation; gastrointestinal cancer NF-κB; inflammation; gastrointestinal cancer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Fang, H.-Y.; Greten, F.R. Cell Autonomous and Non-Autonomous Functions of IKKβ and NF-κB during the Pathogenesis of Gastrointestinal Tumors. Cancers 2011, 3, 2214-2222.

AMA Style

Fang H-Y, Greten FR. Cell Autonomous and Non-Autonomous Functions of IKKβ and NF-κB during the Pathogenesis of Gastrointestinal Tumors. Cancers. 2011; 3(2):2214-2222.

Chicago/Turabian Style

Fang, Hsin-Yu; Greten, Florian R. 2011. "Cell Autonomous and Non-Autonomous Functions of IKKβ and NF-κB during the Pathogenesis of Gastrointestinal Tumors." Cancers 3, no. 2: 2214-2222.


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