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Cell Autonomous and Non-Autonomous Functions of IKKβ and NF-κB during the Pathogenesis of Gastrointestinal Tumors
Institute of Molecular Immunology, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str. 22, Munich 81675, Germany
* Author to whom correspondence should be addressed.
Received: 6 February 2011; in revised form: 4 April 2011 / Accepted: 14 April 2011 / Published: 28 April 2011
Abstract: Genetic studies describing a link between cancer and inflammation have increased recently. Activation of the transcription factor nuclear factor-κB (NF-κB) and its effector pathways has been proposed to be the missing link between these two processes. NF-κB is persistently activated in several types of tumors. However, NF-κB has a distinct role in cancer cells and in inflammatory cells. While in tumor cells NF-κB controls cell survival, in inflammatory cells NF-κB activates genes that encode pro-inflammatory cytokines which further act in a paracrine manner within the tumor microenvironment to contribute to tumorigenesis. Inactivation of NF-κB can also reduce chemoresistance and radioresistance of cancer cells. Therefore, specific NF-κB inhibition in combination with cytotoxic drugs and/or irradiation represents a very promising strategy for cancer therapy.
Keywords: NF-κB; inflammation; gastrointestinal cancer
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Cite This Article
MDPI and ACS Style
Fang, H.-Y.; Greten, F.R. Cell Autonomous and Non-Autonomous Functions of IKKβ and NF-κB during the Pathogenesis of Gastrointestinal Tumors. Cancers 2011, 3, 2214-2222.
Fang H-Y, Greten FR. Cell Autonomous and Non-Autonomous Functions of IKKβ and NF-κB during the Pathogenesis of Gastrointestinal Tumors. Cancers. 2011; 3(2):2214-2222.
Fang, Hsin-Yu; Greten, Florian R. 2011. "Cell Autonomous and Non-Autonomous Functions of IKKβ and NF-κB during the Pathogenesis of Gastrointestinal Tumors." Cancers 3, no. 2: 2214-2222.