Harnessing Dendritic Cells for Tumor Antigen Presentation
AbstractDendritic cells (DC) are professional antigen presenting cells that are crucial for the induction of anti-tumor T cell responses. As a consequence, research has focused on the harnessing of DCs for therapeutic interventions. Although current strategies employing ex vivo-generated and tumor-antigen loaded DCs have been proven feasible, there are still many obstacles to overcome in order to improve clinical trial successes and offset the cost and complexity of customized cell therapy. This review focuses on one of these obstacles and a pivotal step for the priming of tumor-specific CD8+ and CD4+ T cells; the in vitro loading of DCs with tumor antigens.
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Nierkens, S.; Janssen, E.M. Harnessing Dendritic Cells for Tumor Antigen Presentation. Cancers 2011, 3, 2195-2213.
Nierkens S, Janssen EM. Harnessing Dendritic Cells for Tumor Antigen Presentation. Cancers. 2011; 3(2):2195-2213.Chicago/Turabian Style
Nierkens, Stefan; Janssen, Edith M. 2011. "Harnessing Dendritic Cells for Tumor Antigen Presentation." Cancers 3, no. 2: 2195-2213.