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Cancers 2011, 3(2), 2195-2213; doi:10.3390/cancers3022195

Harnessing Dendritic Cells for Tumor Antigen Presentation

1 Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Geert Grooteplein 28, Nijmegen 6525 GA, The Netherlands 2 Division of Molecular Immunology, Cincinnati Children’s Hospital Research Foundation, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
* Author to whom correspondence should be addressed.
Received: 14 March 2011 / Revised: 14 April 2011 / Accepted: 19 April 2011 / Published: 26 April 2011
(This article belongs to the Special Issue Cancer Vaccines and Immunotherapy)
View Full-Text   |   Download PDF [229 KB, 27 April 2011; original version 26 April 2011]


Dendritic cells (DC) are professional antigen presenting cells that are crucial for the induction of anti-tumor T cell responses. As a consequence, research has focused on the harnessing of DCs for therapeutic interventions. Although current strategies employing ex vivo-generated and tumor-antigen loaded DCs have been proven feasible, there are still many obstacles to overcome in order to improve clinical trial successes and offset the cost and complexity of customized cell therapy. This review focuses on one of these obstacles and a pivotal step for the priming of tumor-specific CD8+ and CD4+ T cells; the in vitro loading of DCs with tumor antigens.
Keywords: dendritic cell; tumor antigen; antigen presentation; antigen processing dendritic cell; tumor antigen; antigen presentation; antigen processing
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Nierkens, S.; Janssen, E.M. Harnessing Dendritic Cells for Tumor Antigen Presentation. Cancers 2011, 3, 2195-2213.

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