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Targeting Apoptosis Signaling in Pancreatic Cancer
Institute for Experimental Cancer Research in Pediatrics, Goethe-University Frankfurt, Komturstr. 3a, 60528 Frankfurt, Germany
Received: 24 November 2010; in revised form: 5 January 2011 / Accepted: 6 January 2011 / Published: 11 January 2011
Abstract: The ability to escape apoptosis or programmed cell death is a hallmark of human cancers, for example pancreatic cancer. This can promote tumorigenesis, since too little cell death by apoptosis disturbs tissue homeostasis. Additionally, defective apoptosis signaling is the underlying cause of failure to respond to current treatment approaches, since therapy-mediated antitumor activity requires the intactness of apoptosis signaling pathways in cancer cells. Thus, the elucidation of defects in the regulation of apoptosis in pancreatic carcinoma can result in the identification of novel targets for therapeutic interference and for exploitation for cancer drug discovery.
Keywords: apoptosis; pancreatic cancer; TRAIL; IAPs; mitochondria
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Cite This Article
MDPI and ACS Style
Fulda, S. Targeting Apoptosis Signaling in Pancreatic Cancer. Cancers 2011, 3, 241-251.
Fulda S. Targeting Apoptosis Signaling in Pancreatic Cancer. Cancers. 2011; 3(1):241-251.
Fulda, Simone. 2011. "Targeting Apoptosis Signaling in Pancreatic Cancer." Cancers 3, no. 1: 241-251.