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• Bao, Q
• Zhao, Y
• Renner, A
• Niess, H
• Seeliger, H
• Jauch, K
• Bruns, C
• [+] on Google Scholar
• Bao, Q
• Zhao, Y
• Renner, A
• Niess, H
• Seeliger, H
• Jauch, K
• Bruns, C
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• Bao, Q
• Zhao, Y
• Renner, A
• Niess, H
• Seeliger, H
• Jauch, K
• Bruns, C

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Cancers 2010, 2(3), 1629-1641; doi:10.3390/cancers2031629

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Cancer Stem Cells in Pancreatic Cancer

Qi Bao ^† , Yue Zhao ^† , Andrea Renner, Hanno Niess, Hendrik Seeliger, Karl-Walter Jauch and Christiane J. Bruns*

Department of Surgery, Ludwig Maximilian University of Munich, Klinikum Grosshadern, Marchioninistr. 15, D-81377, Munich, Germany ^† These authors contributed equally to this work.

* Author to whom correspondence should be addressed.

Received: 2 July 2010; in revised form: 29 July 2010 / Accepted: 18 August 2010 / Published: 19 August 2010

(This article belongs to the Special Issue Pancreatic Cancer)

Download PDF Full-Text [894 KB, uploaded 19 August 2010 14:10 CEST]

Abstract: Pancreatic cancer is an aggressive malignant solid tumor well-known by early metastasis, local invasion, resistance to standard chemo- and radiotherapy and poor prognosis. Increasing evidence indicates that pancreatic cancer is initiated and propagated by cancer stem cells (CSCs). Here we review the current research results regarding CSCs in pancreatic cancer and discuss the different markers identifying pancreatic CSCs. This review will focus on metastasis, microRNA regulation and anti-CSC therapy in pancreatic cancer.

Keywords: cancer stem cells; pancreatic cancer; signaling pathways; metastasis; CSC-related therapy; microRNAs

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