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Cancers 2010, 2(2), 338-363; doi:10.3390/cancers2020338
Review

The "Two-Faced" Effects of Reactive Oxygen Species and the Lipid Peroxidation Product 4-Hydroxynonenal in the Hallmarks of Cancer

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Received: 23 February 2010; in revised form: 18 March 2010 / Accepted: 25 March 2010 / Published: 30 March 2010
(This article belongs to the Special Issue Oxidative Stress and Cancer)
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Abstract: Reacytive Oxygen Species (ROS) have long been considered to be involved in the initiation, progression and metastasis of cancer. However, accumulating evidence points to the benefical role of ROS. Moreover, ROS production, leading to apoptosis, is the mechanism by which many chemotherapeutic agents can act. Beside direct actions, ROS elicit lipid peroxidation, leading to the production of 4-hydroxynoneal (HNE). Interestingly, HNE also seems to have a dual behaviour with respect to cancer. In this review we present recent literature data which outline the "two-faced" character of oxidative stress and lipid peroxidation in carcinogenesis and in the hallmarks of cancer.
Keywords: oxidative stress; lipid peroxidation; ROS; 4-hydroxynonenal; carcinogenesis; hallmarks of cancer oxidative stress; lipid peroxidation; ROS; 4-hydroxynonenal; carcinogenesis; hallmarks of cancer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Pizzimenti, S.; Toaldo, C.; Pettazzoni, P.; Dianzani, M.U.; Barrera, G. The "Two-Faced" Effects of Reactive Oxygen Species and the Lipid Peroxidation Product 4-Hydroxynonenal in the Hallmarks of Cancer. Cancers 2010, 2, 338-363.

AMA Style

Pizzimenti S, Toaldo C, Pettazzoni P, Dianzani MU, Barrera G. The "Two-Faced" Effects of Reactive Oxygen Species and the Lipid Peroxidation Product 4-Hydroxynonenal in the Hallmarks of Cancer. Cancers. 2010; 2(2):338-363.

Chicago/Turabian Style

Pizzimenti, Stefania; Toaldo, Cristina; Pettazzoni, Piergiorgio; Dianzani, Mario U.; Barrera, Giuseppina. 2010. "The "Two-Faced" Effects of Reactive Oxygen Species and the Lipid Peroxidation Product 4-Hydroxynonenal in the Hallmarks of Cancer." Cancers 2, no. 2: 338-363.


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