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Cancers 2010, 2(2), 338-363; doi:10.3390/cancers2020338

The "Two-Faced" Effects of Reactive Oxygen Species and the Lipid Peroxidation Product 4-Hydroxynonenal in the Hallmarks of Cancer

Department of Medicine and Experimental Oncology, Section of General Pathology, University of Turin, Corso Raffaello 30, 10153 Turin, Italy
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Received: 23 February 2010 / Revised: 18 March 2010 / Accepted: 25 March 2010 / Published: 30 March 2010
(This article belongs to the Special Issue Oxidative Stress and Cancer)
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Abstract

Reacytive Oxygen Species (ROS) have long been considered to be involved in the initiation, progression and metastasis of cancer. However, accumulating evidence points to the benefical role of ROS. Moreover, ROS production, leading to apoptosis, is the mechanism by which many chemotherapeutic agents can act. Beside direct actions, ROS elicit lipid peroxidation, leading to the production of 4-hydroxynoneal (HNE). Interestingly, HNE also seems to have a dual behaviour with respect to cancer. In this review we present recent literature data which outline the "two-faced" character of oxidative stress and lipid peroxidation in carcinogenesis and in the hallmarks of cancer. View Full-Text
Keywords: oxidative stress; lipid peroxidation; ROS; 4-hydroxynonenal; carcinogenesis; hallmarks of cancer oxidative stress; lipid peroxidation; ROS; 4-hydroxynonenal; carcinogenesis; hallmarks of cancer
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Pizzimenti, S.; Toaldo, C.; Pettazzoni, P.; Dianzani, M.U.; Barrera, G. The "Two-Faced" Effects of Reactive Oxygen Species and the Lipid Peroxidation Product 4-Hydroxynonenal in the Hallmarks of Cancer. Cancers 2010, 2, 338-363.

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