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Cancers 2018, 10(1), 3; doi:10.3390/cancers10010003

Lipid Metabolism and Lipid Droplets in Pancreatic Cancer and Stellate Cells

1
Department of Visceral, Vascular and Endocrine Surgery, Halle University Hospital, Martin-Luther University Halle-Wittenberg, Halle 06120, Germany
2
Department of General, Visceral and Vascular Surgery, BG Hospital Bergmanstrost, Halle 06112, Germany
*
Author to whom correspondence should be addressed.
Received: 30 November 2017 / Revised: 19 December 2017 / Accepted: 20 December 2017 / Published: 23 December 2017
(This article belongs to the Special Issue Latest Development in Pancreatic Cancer)
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Abstract

Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second deadliest cancer by 2030, and the overall 5-year survival rate is currently less than 7%. Cancer cells frequently exhibit reprogramming of their metabolic activity. It is increasingly recognized that aberrant de novo lipid synthesis and reprogrammed lipid metabolism are both associated with the development and progression of various cancers, including pancreatic cancer. In this review, the current knowledge about lipid metabolism and lipid droplets in pancreatic cancer is discussed. In the first part, molecular mechanisms of lipid metabolism and roles of enzymes involved in lipid metabolism which are relevant for pancreatic cancer research are presented. Further, preclinical studies and clinical trials with drugs/inhibitors targeting cancer metabolic systems in cancer are summarized. An increase of our knowledge in lipid metabolism in pancreatic cancer cells and in tumor stroma is important for developing novel strategies of future individualized therapies of pancreatic cancer. View Full-Text
Keywords: pancreatic ductal adenocarcinoma; pancreatic stellate cells; lipid metabolism; lipid droplets; reprogramming in lipid metabolism pancreatic ductal adenocarcinoma; pancreatic stellate cells; lipid metabolism; lipid droplets; reprogramming in lipid metabolism
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Sunami, Y.; Rebelo, A.; Kleeff, J. Lipid Metabolism and Lipid Droplets in Pancreatic Cancer and Stellate Cells. Cancers 2018, 10, 3.

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