Table of Contents
Cancers, Volume 10, Issue 1 (January 2018)
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Cover Story (view full-size image) In cancer, not only mutated proteins may appear, but also normal proteins may change in quantity [...] Read more. In cancer, not only mutated proteins may appear, but also normal proteins may change in quantity and localization, being involved in the pathogenesis of the disease. After having described the normal distribution of protein kinase A (PKA) regulatory subunits in the brain of various species, and modifications during development and aging, we showed a hotspot of PKA R2A in the Golgi apparatus of glioblastoma cells. Now, we report the same finding, which appears specific to glioblastoma, in a series of human glioblastoma samples, compared to other tumors and normal brain. We therefore conclude, R2A may be a diagnostic or therapeutic target exploitable for glioblastoma. View this paper