Next Article in Journal / Special Issue
Targeting Pancreatic Cancer Cell Plasticity: The Latest in Therapeutics
Previous Article in Journal
Acknowledgement to Reviewers of Cancers in 2017
Previous Article in Special Issue
Immune Evasion in Pancreatic Cancer: From Mechanisms to Therapy
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessReview
Cancers 2018, 10(1), 16; doi:10.3390/cancers10010016

Locally Advanced Pancreatic Cancer: A Review of Local Ablative Therapies

Department of Radiology and Nuclear Medicine, VU University Medical Center, 1081 HV Amsterdam, The Netherlands
Author to whom correspondence should be addressed.
Received: 30 November 2017 / Revised: 3 January 2018 / Accepted: 4 January 2018 / Published: 10 January 2018
(This article belongs to the Special Issue Latest Development in Pancreatic Cancer)
View Full-Text   |   Download PDF [405 KB, uploaded 10 January 2018]   |  


Pancreatic cancer is typically characterized by its aggressive tumor growth and dismal prognosis. Approximately 30% of patients with pancreatic cancer present with locally advanced disease, broadly defined as having a tumor-to-artery interface >180°, having an unreconstructable portal vein or superior mesenteric vein and no signs of metastatic disease. These patients are currently designated to palliative systemic chemotherapy, though median overall survival remains poor (approximately 11 months). Therefore, several innovative local therapies have been investigated as new treatment options for locally advanced pancreatic cancer (LAPC). This article provides an overview of available data with regard to morbidity and oncological outcome of novel local therapies for LAPC. View Full-Text
Keywords: locally advanced pancreatic cancer (LAPC); pancreatic cancer; local ablative therapies locally advanced pancreatic cancer (LAPC); pancreatic cancer; local ablative therapies

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Ruarus, A.; Vroomen, L.; Puijk, R.; Scheffer, H.; Meijerink, M. Locally Advanced Pancreatic Cancer: A Review of Local Ablative Therapies. Cancers 2018, 10, 16.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top