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Micromachines 2018, 9(1), 36; https://doi.org/10.3390/mi9010036

Hydrogel Fiber Cultivation Method for Forming Bacterial Cellulose Microspheres

1
School of Integrated Design Engineering, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Kanagawa, Japan
2
Department of Mechanical Engineering, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Kanagawa, Japan
*
Author to whom correspondence should be addressed.
Received: 8 December 2017 / Revised: 28 December 2017 / Accepted: 15 January 2018 / Published: 17 January 2018
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Abstract

Forming microspheres or microbeads from nanofibrous materials has recently attracted research interest for their applications in various fields, because these structures greatly impact cellular behaviors and functions. However, conventional methods of preparing microspheres or microbeads have limitations, such as limited variety of material. Here, we propose a new fabrication process for forming a nanofibrous microsphere composed of bacterial cellulose (BC), which is synthesized through fermentation by specific bacteria. The process uses a hydrogel fiber containing spherical cavities. The bacteria encapsulated into the cavities produce BC, resulting in the formation of BC microspheres. Because of its simplicity, robustness, and cost-effectiveness, this process is promising for applications, such as in biochemical engineering and cell delivery systems. View Full-Text
Keywords: microbeads; microcarriers; microbes; microfabrication; microfluidics; droplet; emulsion; monodispersity microbeads; microcarriers; microbes; microfabrication; microfluidics; droplet; emulsion; monodispersity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Higashi, K.; Miki, N. Hydrogel Fiber Cultivation Method for Forming Bacterial Cellulose Microspheres. Micromachines 2018, 9, 36.

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