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Micromachines 2017, 8(9), 265; doi:10.3390/mi8090265

A Single-Use, Self-Powered, Paper-Based Sensor Patch for Detection of Exercise-Induced Hypoglycemia

Bioelectronics & Microsystems Laboratory, Department of Electrical & Computer Engineering, State University of New York-Binghamton, Binghamton, NY 13902, USA
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Received: 27 July 2017 / Revised: 23 August 2017 / Accepted: 27 August 2017 / Published: 31 August 2017
(This article belongs to the Special Issue Paper-Based Transducers and Electronics)
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Abstract

We report a paper-based self-powered sensor patch for prevention and management of exercise-induced hypoglycemia. The article describes the fabrication, in vitro, and in vivo characterization of the sensor for glucose monitoring in human sweat. This wearable, non-invasive, single-use biosensor integrates a vertically stacked, paper-based glucose/oxygen enzymatic fuel cell into a standard Band-Aid adhesive patch. The paper-based device attaches directly to skin, wicks sweat by using capillary forces to a reservoir where chemical energy is converted to electrical energy, and monitors glucose without external power and sophisticated readout instruments. The device utilizes (1) a 3-D paper-based fuel cell configuration, (2) an electrically conducting microfluidic reservoir for a high anode surface area and efficient mass transfer, and (3) a direct electron transfer between glucose oxidase and anodes for enhanced electron discharge properties. The developed sensor shows a high linearity of current at 0.02–1.0 mg/mL glucose centration (R2 = 0.989) with a high sensitivity of 1.35 µA/mM. View Full-Text
Keywords: sweat sensor patch; self-powered glucose sensor; enzymatic fuel cell; paper-based device; exercise-induced hypoglycemia sweat sensor patch; self-powered glucose sensor; enzymatic fuel cell; paper-based device; exercise-induced hypoglycemia
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Cho, E.; Mohammadifar, M.; Choi, S. A Single-Use, Self-Powered, Paper-Based Sensor Patch for Detection of Exercise-Induced Hypoglycemia. Micromachines 2017, 8, 265.

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