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Micromachines 2017, 8(7), 216; doi:10.3390/mi8070216

Development of the Electric Equivalent Model for the Cytoplasmic Microinjection of Small Adherent Cells

1
Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Hong Kong, China
2
Department of Biomedical Engineering, Anhui Medical University, Hefei 230032, China
3
Centre for Robotics and Automation, City University of Hong Kong, Hong Kong, China
*
Author to whom correspondence should be addressed.
Received: 2 May 2017 / Revised: 25 June 2017 / Accepted: 4 July 2017 / Published: 8 July 2017
(This article belongs to the Special Issue Microdevices and Microsystems for Cell Manipulation)
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Abstract

A novel approach utilizing current feedback for the cytoplasmic microinjection of biological cells is proposed. In order to realize the cytoplasmic microinjection on small adherent cells (diameter < 30 μm and thickness < 10 μm), an electrical model is built and analyzed according to the electrochemical properties of target cells. In this study, we have verified the effectiveness of the current measurement for monitoring the injection process and the study of ion channel activities for verifying the cell viability of the cells after the microinjection. View Full-Text
Keywords: cell cytoplasmic microinjection; small adherent cells; equivalent-circuit model cell cytoplasmic microinjection; small adherent cells; equivalent-circuit model
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Chan, F.H.L.; Yang, R.; Lai, K.W.C. Development of the Electric Equivalent Model for the Cytoplasmic Microinjection of Small Adherent Cells. Micromachines 2017, 8, 216.

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