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Micromachines 2016, 7(2), 28; doi:10.3390/mi7020028

Development of a Whole Blood Paper-Based Device for Phenylalanine Detection in the Context of PKU Therapy Monitoring

1
School of Chemical, Biological, and Environmental Engineering, Oregon State University, Corvallis, OR 97331, USA
2
Departments of Pathology and Genome Sciences, University of Washington, Seattle, WA 98195, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Sergey S. Shevkoplyas
Received: 19 December 2015 / Revised: 4 February 2016 / Accepted: 4 February 2016 / Published: 15 February 2016
(This article belongs to the Special Issue Paper-Based Microfluidic Devices for Point-of-Care Diagnostics)
View Full-Text   |   Download PDF [1666 KB, uploaded 15 February 2016]   |  

Abstract

Laboratory-based testing does not allow for the sufficiently rapid return of data to enable optimal therapeutic monitoring of patients with metabolic diseases such as phenylketonuria (PKU). The typical turn-around time of several days for current laboratory-based testing is too slow to be practically useful for effective monitoring or optimizing therapy. This report describes the development of a rapid, paper-based, point-of-care device for phenylalanine detection using a small volume (40 μL) of whole blood. The quantitative resolution and reproducibility of this device with instrumented readout are described, together with the potential use of this device for point-of-care monitoring by PKU patients. View Full-Text
Keywords: paper-based device; whole-blood assay; phenylalanine detection; colorimetric readout; phenylketonuria paper-based device; whole-blood assay; phenylalanine detection; colorimetric readout; phenylketonuria
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Robinson, R.; Wong, L.; Monnat, R.J.; Fu, E. Development of a Whole Blood Paper-Based Device for Phenylalanine Detection in the Context of PKU Therapy Monitoring. Micromachines 2016, 7, 28.

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