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Micromachines 2015, 6(9), 1406-1420; doi:10.3390/mi6091406

OLED Hybrid Integrated Polymer Microfluidic Biosensing for Point of Care Testing

1
Optical Bio Microsystems Laboratory, Department of Mechanical and Industrial Engineering, Concordia University, 1515 St. Catherine W., Montréal, QC H3G 2W1, Canada
2
Informatique, Université du Québec à Montréal, 201 President-Kennedy av., Montréal, QC H2X 3Y7, Canada
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Joost Lötters
Received: 7 November 2014 / Revised: 30 July 2015 / Accepted: 6 August 2015 / Published: 22 September 2015
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Abstract

This paper reports a microfluidic platform with external hybrid integration of an organic light emitting diode (OLED) as an excitation source. This device can be used as a simple and cost effective biosensing element. The device is capable of rapid in-situ detection of biological elements such as sensing of interaction of antigen with fluorescent tagged antibody conjugates. These portable microfluidic systems have great potential for use an OLED in a single chip with very high accuracy and sensitivity for various point-of-care (POC) diagnosis and lab on a chip (LOC) applications, as the miniaturization of the biosensor is essential for handling smaller sample volumes in order to achieve high throughput. The biosensing element was successfully tested to detect anti-sheep IgG conjugates tagged to Alexafluor using a fluorescence based immunoassay method. View Full-Text
Keywords: BioMEMS; hybrid integrated microfluidic biosensor; organic light emitting diode; electroluminescence; polydimethylsiloaxane; immunoassay; point-of-care testing BioMEMS; hybrid integrated microfluidic biosensor; organic light emitting diode; electroluminescence; polydimethylsiloaxane; immunoassay; point-of-care testing
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Acharya, A.; Packirisamy, M.; Izquierdo, R. OLED Hybrid Integrated Polymer Microfluidic Biosensing for Point of Care Testing. Micromachines 2015, 6, 1406-1420.

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