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Micromachines 2015, 6(10), 1546-1559; doi:10.3390/mi6101438

Paper-Based Electrodeposition Chip for 3D Alginate Hydrogel Formation

1
Department of Mechanical and Biomedical Engineering, City University of Hong Kong, No. 83, Tat Chee Ave, Kowloon, Hong Kong, China
2
College of Electromechanical Engineering, University of Petroleum (East China), No. 66, ChangjiangWest Road, Huangdao District, Qingdao 266600, China
3
City University of Hong Kong Shenzhen Research Institute, 8 Yuexing 1st Road, Shenzhen 518000, China
This paper is an extended version of our paper published in the 10th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems (IEEE NEMS 2015), Xi’an, China, 7–11 April 2015.
*
Author to whom correspondence should be addressed.
Academic Editors: Wen Jung Li and Ting-Hsuan Chen
Received: 6 September 2015 / Accepted: 13 October 2015 / Published: 15 October 2015
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Abstract

Hydrogel has been regarded as one significant biomaterial in biomedical and tissue engineering due to its high biocompatibility. This paper proposes a novel method to pattern calcium alginate hydrogel in a 3D way via electrodeposition process based on a piece of paper. Firstly, one insulating paper with patterned holes is placed on one indium tin oxide (ITO) glass surface, which is put below another ITO glass. Then, 1% sodium alginate solution with 0.25% CaCO3 nano particles is filled between these two glasses. In the bottom glass, patterns of electrodes followed patterns of holes on the insulating layer. Hydrogel forms on patterned electrodes when electrochemical potential is applied due to electrodeposition. The experiments demonstrate that the pattern of alginate hydrogels follows the pattern of electrodes exactly. In addition, the hydrogel’s height is controllable by applied potential and reaction time. An equivalent circuit model and a hydrogel growth model have been built to predict the electrodeposition current and hydrogel’s growth. This method for gel formation is easy and cheap since the main material is one piece of insulated paper, which provides an easy and controllable method for 3D hydrogel patterning. View Full-Text
Keywords: alginate hydrogel; 3D cell culture; electrodeposition; 3D hydrogel patterning; insulating layer alginate hydrogel; 3D cell culture; electrodeposition; 3D hydrogel patterning; insulating layer
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Wan, W.; Dai, G.; Zhang, L.; Shen, Y. Paper-Based Electrodeposition Chip for 3D Alginate Hydrogel Formation. Micromachines 2015, 6, 1546-1559.

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