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Toxins 2017, 9(2), 43; doi:10.3390/toxins9020043

Involvement of FvSet1 in Fumonisin B1 Biosynthesis, Vegetative Growth, Fungal Virulence, and Environmental Stress Responses in Fusarium verticillioides

Key Laboratory of Monitoring and Management of Crop Diseases and Pest Insects, Department of Plant Pathology, College of Plant Protection, Nanjing Agricultural University, Ministry of Education, Nanjing 210095, China
These author contributed equally to this work.
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Academic Editors: Susanne Vogelgsang and Yang Liu
Received: 14 December 2016 / Revised: 15 January 2017 / Accepted: 17 January 2017 / Published: 24 January 2017
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Abstract

Fusarium verticillioides (teleomorph, Gibberella moniliformis) is an important plant pathogen that causes seedling blight, stalk rot, and ear rot in maize (Zea mays). During infection, F. verticillioides produce fumonsins B1 (FB1) that pose a serious threat to human and animal health. Recent studies showed that Set1, a methyltransferase of H3K4, was responsible for toxin biosynthesis in filamentous fungi. However, to date, the regulation of FvSet1 on FB1 biosynthesis remains unclear. In the current study, we identified only one Set1 ortholog in F. verticillioides (FvSet1) and found that the deletion of FvSET1 led to various defects in fungal growth and pathogenicity. More interestingly, the FvSET1 deletion mutant (ΔFvSet1) showed a significant defect in FB1 biosynthesis and lower expression levels of FUM genes. FvSet1 was also found to play an important role in the responses of F. verticillioides to multiple environmental stresses via regulating the phosphorylation of FvMgv1 and FvHog1. Taken together, these results indicate that FvSet1 plays essential roles in the regulation of FB1 biosynthesis, fungal growth and virulence, as well as various stress responses in F. verticillioides. View Full-Text
Keywords: Fusarium verticillioides; FvSet1; fumonisin B1; fungal growth and virulence; stress responses Fusarium verticillioides; FvSet1; fumonisin B1; fungal growth and virulence; stress responses
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MDPI and ACS Style

Gu, Q.; Tahir, H.A.S.; Zhang, H.; Huang, H.; Ji, T.; Sun, X.; Wu, L.; Wu, H.; Gao, X. Involvement of FvSet1 in Fumonisin B1 Biosynthesis, Vegetative Growth, Fungal Virulence, and Environmental Stress Responses in Fusarium verticillioides. Toxins 2017, 9, 43.

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