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Toxins 2017, 9(11), 346; https://doi.org/10.3390/toxins9110346

The Aromatic Head Group of Spider Toxin Polyamines Influences Toxicity to Cancer Cells

1
Centre for Biodiscovery and Molecular Development of Therapeutics, AITHM, James Cook University, Cairns, QLD 4878, Australia
2
QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia
3
Centre for Tropical Environmental and Sustainable Sciences, James Cook University, Cairns, QLD 4878, Australia
4
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
5
School of Biomedical Sciences, University of Queensland, Brisbane, QLD 4072, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: Hang Fai (Henry) Kwok
Received: 5 September 2017 / Revised: 22 October 2017 / Accepted: 23 October 2017 / Published: 27 October 2017
(This article belongs to the Section Animal Venoms)
View Full-Text   |   Download PDF [2570 KB, uploaded 28 November 2017]   |  

Abstract

Spider venoms constitute incredibly diverse libraries of compounds, many of which are involved in prey capture and defence. Polyamines are often prevalent in the venom and target ionotropic glutamate receptors. Here we show that a novel spider polyamine, PA366, containing a hydroxyphenyl-based structure is present in the venom of several species of tarantula, and has selective toxicity against MCF-7 breast cancer cells. By contrast, a polyamine from an Australian funnel-web spider venom, which contains an identical polyamine tail to PA366 but an indole-based head-group, is only cytotoxic at high concentrations. Our results suggest that the ring structure plays a role in the cytotoxicity and that modification to the polyamine head group might lead to more potent and selective compounds with potential as novel cancer treatments. View Full-Text
Keywords: spider venom; NMR spectroscopy; polyamine; cancer; cytotoxicity spider venom; NMR spectroscopy; polyamine; cancer; cytotoxicity
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Wilson, D.; Boyle, G.M.; McIntyre, L.; Nolan, M.J.; Parsons, P.G.; Smith, J.J.; Tribolet, L.; Loukas, A.; Liddell, M.J.; Rash, L.D.; Daly, N.L. The Aromatic Head Group of Spider Toxin Polyamines Influences Toxicity to Cancer Cells. Toxins 2017, 9, 346.

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