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Toxins 2016, 8(5), 142; doi:10.3390/toxins8050142

Helicobacter pylori vacA Genotypes in Chronic Gastritis and Gastric Carcinoma Patients from Macau, China

1
i3S—Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto 4200-135, Portugal
2
Ipatimup—Institute of Molecular Pathology and Immunology of the University of Porto, Porto 4200-135, Portugal
3
Centro Hospitalar Conde São Januário, Macau, China
4
Department of Pathology and Oncology, Faculty of Medicine of the University of Porto, Porto 4200-319, Portugal
5
Department of Pathology, Centro Hospitalar São João, Porto 4200-319, Portugal
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Timothy L. Cover
Received: 28 February 2016 / Revised: 11 April 2016 / Accepted: 29 April 2016 / Published: 5 May 2016
(This article belongs to the Special Issue Vacuolating Toxin)
View Full-Text   |   Download PDF [248 KB, uploaded 5 May 2016]   |  

Abstract

Helicobacter pylori is the major triggering factor for gastric carcinoma, but only a small proportion of infected patients develop this disease. Differences in virulence observed among H. pylori strains, namely in the vacuolating cytotoxin vacA gene, may contribute to this discrepancy. Infection with vacA s1, i1 and m1 strains increases the risk for progression of gastric premalignant lesions and for gastric carcinoma. However, in East Asian countries most of the H. pylori strains are vacA s1, regardless of the patients’ clinical status, and the significance of the vacA i1 and m1 genotypes for gastric carcinoma in this geographic area remains to be fully elucidated. The aim of the present study was to investigate this relationship in 290 patients from Macau, China. Using very sensitive and accurate genotyping methods, we detected infection with vacA i1 and with vacA m1 strains in, respectively, 85.2% and 52.6% of the patients that were infected with single genotypes. The prevalence of cagA-positive strains was 87.5%. No significant associations were observed between vacA genotypes or cagA and gastric carcinoma. It is worth noting that 37.5% of the infected patients had coexistence of H. pylori strains with different vacA genotypes. Additional studies directed to other H. pylori virulence factors should be performed to identify high risk patients in East Asia. View Full-Text
Keywords: Helicobacter pylori; vacA gene; genotyping; gastric carcinoma; China Helicobacter pylori; vacA gene; genotyping; gastric carcinoma; China
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MDPI and ACS Style

Pinto-Ribeiro, I.; Ferreira, R.M.; Batalha, S.; Hlaing, T.; Wong, S.I.; Carneiro, F.; Figueiredo, C. Helicobacter pylori vacA Genotypes in Chronic Gastritis and Gastric Carcinoma Patients from Macau, China. Toxins 2016, 8, 142.

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