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Toxins 2016, 8(5), 131; doi:10.3390/toxins8050131

Regulatory T Cells Contribute to the Inhibition of Radiation-Induced Acute Lung Inflammation via Bee Venom Phospholipase A2 in Mice

Department of Physiology, College of Korean Medicine, Kyung Hee University, Seoul 130-701, South Korea
Department of Radiation Oncology, Yonsei University College of Medicine, Seoul 120-752, South Korea
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Academic Editor: Ren Lai
Received: 10 March 2016 / Revised: 23 April 2016 / Accepted: 26 April 2016 / Published: 30 April 2016
(This article belongs to the Section Animal Venoms)
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Bee venom has long been used to treat various inflammatory diseases, such as rheumatoid arthritis and multiple sclerosis. Previously, we reported that bee venom phospholipase A2 (bvPLA2) has an anti-inflammatory effect through the induction of regulatory T cells. Radiotherapy is a common anti-cancer method, but often causes adverse effects, such as inflammation. This study was conducted to evaluate the protective effects of bvPLA2 in radiation-induced acute lung inflammation. Mice were focally irradiated with 75 Gy of X-rays in the lung and administered bvPLA2 six times after radiation. To evaluate the level of inflammation, the number of immune cells, mRNA level of inflammatory cytokine, and histological changes in the lung were measured. BvPLA2 treatment reduced the accumulation of immune cells, such as macrophages, neutrophils, lymphocytes, and eosinophils. In addition, bvPLA2 treatment decreased inflammasome-, chemokine-, cytokine- and fibrosis-related genes’ mRNA expression. The histological results also demonstrated the attenuating effect of bvPLA2 on radiation-induced lung inflammation. Furthermore, regulatory T cell depletion abolished the therapeutic effects of bvPLA2 in radiation-induced pneumonitis, implicating the anti-inflammatory effects of bvPLA2 are dependent upon regulatory T cells. These results support the therapeutic potential of bvPLA2 in radiation pneumonitis and fibrosis treatments. View Full-Text
Keywords: bee venom; phospholipase A2; inflammation; radiotherapy; regulatory T cells bee venom; phospholipase A2; inflammation; radiotherapy; regulatory T cells

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Shin, D.; Lee, G.; Sohn, S.-H.; Park, S.; Jung, K.-H.; Lee, J.M.; Yang, J.; Cho, J.; Bae, H. Regulatory T Cells Contribute to the Inhibition of Radiation-Induced Acute Lung Inflammation via Bee Venom Phospholipase A2 in Mice. Toxins 2016, 8, 131.

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