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Toxins 2016, 8(2), 42; doi:10.3390/toxins8020042

Acetylated Deoxynivalenol Generates Differences of Gene Expression that Discriminate Trichothecene Toxicity

Applied Microbiology Division, National Food Research Institute, National Agriculture and Food Research Organization (NARO), 2-1-12 Kannon-dai, Tsukuba, Ibaraki 305-8642, Japan
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Academic Editor: Sven Dänicke
Received: 11 December 2015 / Accepted: 3 February 2016 / Published: 6 February 2016
(This article belongs to the Collection Fusarium Toxins – Relevance for Human and Animal Health)
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Abstract

Deoxynivalenol (DON), which is a toxic secondary metabolite generated by Fusarium species, is synthesized through two separate acetylation pathways. Both acetylation derivatives, 3-acetyl-DON (3ADON) and 15-acetyl-DON (15ADON), also contaminate grain and corn widely. These derivatives are deacetylated via a variety of processes after ingestion, so it has been suggested that they have the same toxicity as DON. However, in the intestinal entry region such as the duodenum, the derivatives might come into contact with intestinal epithelium cells because metabolism by microflora or import into the body has not progressed. Therefore, the differences of toxicity between DON and these derivatives need to be investigated. Here, we observed gene expression changes in the yeast pdr5Δ mutant strain under concentration-dependent mycotoxin exposure conditions. 15ADON exposure induced significant gene expression changes and DON exposure generally had a similar but smaller effect. However, the glucose transporter genes HXT2 and HXT4 showed converse trends. 3ADON also induced a different expression trend in these genes than DON and 15ADON. These differences in gene expression suggest that DON and its derivatives have different effects on cells. View Full-Text
Keywords: DON; acetylated derivative; toxicity; gene expression DON; acetylated derivative; toxicity; gene expression
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Suzuki, T.; Iwahashi, Y. Acetylated Deoxynivalenol Generates Differences of Gene Expression that Discriminate Trichothecene Toxicity. Toxins 2016, 8, 42.

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