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Toxins 2016, 8(11), 307; doi:10.3390/toxins8110307

Pseudomonas aeruginosa Type III Secretory Toxin ExoU and Its Predicted Homologs

Department of Anesthesiology, School of Medicine, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
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Author to whom correspondence should be addressed.
Academic Editor: Vernon Tesh
Received: 7 September 2016 / Revised: 20 October 2016 / Accepted: 21 October 2016 / Published: 26 October 2016
(This article belongs to the Section Bacterial Toxins)
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Abstract

Pseudomonas aeruginosa ExoU, a type III secretory toxin and major virulence factor with patatin-like phospholipase activity, is responsible for acute lung injury and sepsis in immunocompromised patients. Through use of a recently updated bacterial genome database, protein sequences predicted to be homologous to Ps. aeruginosa ExoU were identified in 17 other Pseudomonas species (Ps. fluorescens, Ps. lundensis, Ps. weihenstephanensis, Ps. marginalis, Ps. rhodesiae, Ps. synxantha, Ps. libanensis, Ps. extremaustralis, Ps. veronii, Ps. simiae, Ps. trivialis, Ps. tolaasii, Ps. orientalis, Ps. taetrolens, Ps. syringae, Ps. viridiflava, and Ps. cannabina) and 8 Gram-negative bacteria from three other genera (Photorhabdus, Aeromonas, and Paludibacterium). In the alignment of the predicted primary amino acid sequences used for the phylogenetic analyses, both highly conserved and nonconserved parts of the toxin were discovered among the various species. Further comparative studies of the predicted ExoU homologs should provide us with more detailed information about the unique characteristics of the Ps. aeruginosa ExoU toxin. View Full-Text
Keywords: ExoU; patatin; phospholipase A2; Pseudomonas aeruginosa; type III secretion system ExoU; patatin; phospholipase A2; Pseudomonas aeruginosa; type III secretion system
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Sawa, T.; Hamaoka, S.; Kinoshita, M.; Kainuma, A.; Naito, Y.; Akiyama, K.; Kato, H. Pseudomonas aeruginosa Type III Secretory Toxin ExoU and Its Predicted Homologs. Toxins 2016, 8, 307.

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