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Toxins 2015, 7(7), 2629-2638; doi:10.3390/toxins7072629

Topographic Relationship between the Supratrochlear Nerve and Corrugator Supercilii Muscle—Can This Anatomical Knowledge Improve the Response to Botulinum Toxin Injections in Chronic Migraine?

1
Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Center, BK21 PLUS Project, Yonsei University College of Dentistry, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Korea
2
Department of Occupational Therapy, Semyung University, Semyungro 65, Jecheonsi, Chungcheongbuk-do 390-711, Korea
3
Department of Oral Medicine, Temporomandibular Joint and Orofacial Pain Clinic, Yonsei University College of Dentistry, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Korea
4
The Chula Soft Cadaver Surgical Training Center and Department of Anatomy, Faculty of Medicine, Chulalongkorn University, 254 Phyathai Road, Patumwan 10330, Bangkok, Thailand
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Bahman Jabbari
Received: 24 February 2015 / Revised: 10 July 2015 / Accepted: 13 July 2015 / Published: 17 July 2015
(This article belongs to the Collection Botulinum Toxins on Human Pain)
View Full-Text   |   Download PDF [875 KB, uploaded 17 July 2015]   |  

Abstract

Chronic migraine has been related to the entrapment of the supratrochlear nerve within the corrugator supercilii muscle. Recently, research has shown that people who have undergone botulinum neurotoxin A injection in frontal regions reported disappearance or alleviation of their migraines. There have been numerous anatomical studies conducted on Caucasians revealing possible anatomical problems leading to migraine; on the other hand, relatively few anatomical studies have been conducted on Asians. Thus, the aim of the present study was to determine the topographic relationship between the supratrochlear nerve and corrugator supercilii muscle in the forehead that may be the cause of migraine. Fifty-eight hemifaces from Korean and Thai cadavers were used for this study. The supratrochlear nerve entered the corrugator supercilii muscle in every case. Type I, in which the supratrochlear nerve emerged separately from the supraorbital nerve at the medial one-third portion of the orbit, was observed in 69% (40/58) of cases. Type II, in which the supratrochlear nerve emerged from the orbit at the same location as the supraorbital nerve, was observed in 31% (18/58) of cases. View Full-Text
Keywords: supratrochlear nerve; corrugator supercilii muscle; chronic migraine; trigger point injection; periorbital region supratrochlear nerve; corrugator supercilii muscle; chronic migraine; trigger point injection; periorbital region
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Lee, H.-J.; Choi, K.-S.; Won, S.-Y.; Apinuntrum, P.; Hu, K.-S.; Kim, S.-T.; Tansatit, T.; Kim, H.-J. Topographic Relationship between the Supratrochlear Nerve and Corrugator Supercilii Muscle—Can This Anatomical Knowledge Improve the Response to Botulinum Toxin Injections in Chronic Migraine? Toxins 2015, 7, 2629-2638.

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