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Addendum published on 5 May 2016, see Toxins 2016, 8(5), 141.

Open AccessArticle
Toxins 2015, 7(12), 5224-5235; doi:10.3390/toxins7124876

Multi-Toxic Endpoints of the Foodborne Mycotoxins in Nematode Caenorhabditis elegans

1
Synergetic Innovation Center of Food Safety and Nutrition, School of Food Science, Jiangnan University, Wuxi, Jiangsu 214122, China
2
Department of Environmental Health Science, University of Georgia, Athens, GA 30602, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Paul Turner
Received: 22 September 2015 / Revised: 11 November 2015 / Accepted: 13 November 2015 / Published: 2 December 2015
(This article belongs to the Section Mycotoxins)
View Full-Text   |   Download PDF [1768 KB, uploaded 2 December 2015]   |  

Abstract

Aflatoxins B1 (AFB1), deoxynivalenol (DON), fumonisin B1 (FB1), T-2 toxin (T-2), and zearalenone (ZEA) are the major foodborne mycotoxins of public health concerns. In the present study, the multiple toxic endpoints of these naturally-occurring mycotoxins were evaluated in Caenorhabditis elegans model for their lethality, toxic effects on growth and reproduction, as well as influence on lifespan. We found that the lethality endpoint was more sensitive for T-2 toxicity with the EC50 at 1.38 mg/L, the growth endpoint was relatively sensitive for AFB1 toxic effects, and the reproduction endpoint was more sensitive for toxicities of AFB1, FB1, and ZEA. Moreover, the lifespan endpoint was sensitive to toxic effects of all five tested mycotoxins. Data obtained from this study may serve as an important contribution to knowledge on assessment of mycotoxin toxic effects, especially for assessing developmental and reproductive toxic effects, using the C. elegans model. View Full-Text
Keywords: aflatoxin B1; Caenorhabditis elegans; deoxynivalenol; fumonisin B1; mycotoxins; T-2 toxin; zearalenone aflatoxin B1; Caenorhabditis elegans; deoxynivalenol; fumonisin B1; mycotoxins; T-2 toxin; zearalenone
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Yang, Z.; Xue, K.S.; Sun, X.; Tang, L.; Wang, J.-S. Multi-Toxic Endpoints of the Foodborne Mycotoxins in Nematode Caenorhabditis elegans. Toxins 2015, 7, 5224-5235.

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