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Toxins 2015, 7(11), 4730-4744; doi:10.3390/toxins7114730

Vitamin D3 and Monomethyl Fumarate Enhance Natural Killer Cell Lysis of Dendritic Cells and Ameliorate the Clinical Score in Mice Suffering from Experimental Autoimmune Encephalomyelitis

1
Department of Physiology, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, POB 1103, Oslo N-0317, Norway
2
College of Medicine, University of Sharjah, Al-Sharja 27272, UAE
*
Author to whom correspondence should be addressed.
Academic Editor: Vernon L. Tesh
Received: 1 July 2015 / Revised: 26 October 2015 / Accepted: 27 October 2015 / Published: 13 November 2015
(This article belongs to the Collection Toxicity and Therapeutic Interventions in the Immune System)
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Abstract

Experimental autoimmune encephalomyelitis (EAE) is a CD4+ T cell mediated inflammatory demyelinating disease that is induced in mice by administration of peptides derived from myelin proteins. We developed EAE in SJL mice by administration of PLP139–151 peptide. The effect of treating these mice with 1α,25-Dihydroxyvitamin D3 (vitamin D3), or with monomethyl fumarate (MMF) was then examined. We observed that both vitamin D3 and MMF inhibited and/or prevented EAE in these mice. These findings were corroborated with isolating natural killer (NK) cells from vitamin D3-treated or MMF-treated EAE mice that lysed immature or mature dendritic cells. The results support and extend other findings indicating that an important mechanism of action for drugs used to treat multiple sclerosis (MS) is to enhance NK cell lysis of dendritic cells. View Full-Text
Keywords: natural killer cells; dendritic cells; experimental autoimmune encephalomyelitis; 1α,25-Dihydroxyvitamin D3; monomethyl fumarate; myelin proteolipid protein natural killer cells; dendritic cells; experimental autoimmune encephalomyelitis; 1α,25-Dihydroxyvitamin D3; monomethyl fumarate; myelin proteolipid protein
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MDPI and ACS Style

Al-Jaderi, Z.; Maghazachi, A.A. Vitamin D3 and Monomethyl Fumarate Enhance Natural Killer Cell Lysis of Dendritic Cells and Ameliorate the Clinical Score in Mice Suffering from Experimental Autoimmune Encephalomyelitis. Toxins 2015, 7, 4730-4744.

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